Simva Plus

by Nabiqasim

Active ingredients: Ezetimibe, Simvastatin, Simvastatin and Ezetimibe

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About Ezetimibe

Hypolipidaemic/Anti-atheroma

Uses

Adjunct to diet in primary hypercholesterolaemia either co-administered with a statin for patients not appropriately controlled with a statin alone, or as monotherapy when a statin is inappropriate or not tolerated. Adjunct to diet in homozygous familial hypercholesterolaemia in combination with a statin and, if necessary, other adjunctive treatments. Adjunct to diet in homozygous familial sitosterolaemia.

How to take it

Adults: 1 tab daily. Children: Under 10 yr, not recommended. Adjunct to statin treatment in primary hypercholesterolaemia and homozygous familial hypercholesterolaemia, ezetimibe alone in primary hypercholesterolaemia if statin inappropriate or not tolerated; adjunct to dietary measures in homozygous sitosterolaemia: 10-18 yr, 10 mg once daily.

Side effects

Headache, abdominal pain, diarrhoea, GI upset, fatigue, abnormal LFTs.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Moderate to severe hepatic impairment, concomitant use with a statin in active liver disease. Precautions: Monitor liver function if giving with a statin. Unexplained muscle weakness or pain; monitor creatine kinase levels if myopathy suspected.

Advice

Take with or without meals. Take medication at the same time each day. Take 2 hours before or 4 hours after bile acid binding agents. Contact prescriber if there is chest pain, palpitations, muscle pain, weakness, skeletal pain, joint pain or increased sweating. Take low-cholesterol diet. Exercise regularly. Try to lose weight.

Full information on Ezetimibe →

Interactions with Ezetimibe

Fibrates, cyclosporin, cholestyramine, colestipol, anticoagulants.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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