Gliclazide

by English

Active ingredients: Gliclazide, Sulphonylurea

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About Gliclazide

Hypoglycaemic excluding Insulin

Uses

Maturity-onset diabetes. Type 2 diabetes.

How to take it

Maturity-onset diabetes: Adults: 40-80 mg daily increasing if necessary to max 320 mg daily. Doses above 160 mg should be taken in two divided doses. Type 2 diabetes: Adults: 30 to 120 mg depending on response, once daily with breakfast, including elderly or those with renal failure. Children: Not recommended.

Side effects

Hypoglycaemia, GI disturbances including nausea, dyspepsia, diarrhoea and constipation. Skin reactions, hepatic failure, hepatitis, jaundice, blood dyscrasias.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Type I diabetes, diabetic ketoacidosis, pre-coma and coma, severe renal or hepatic insufficiency. Surgery, severe trauma, infections. Porphyria. Precautions: Children. Mild to moderate renal or hepatic impairment, obesity, G6PD deficiency, risk factors for hypoglycaemia ( incl malnourishment, severe vascular disease, adrenal or pituitary insufficiency, hypothyroidism).

Advice

Take with meals. Do not chew or crush tablets, swallow whole.

Full information on Gliclazide →

Interactions with Gliclazide

Miconazole, phenylbutazone, alcohol, insulin, acarbose, biguanides, beta-blockers, fluconazole, ACE inhibitors, H2 receptor antagonists, MAOIs, sulphonamides, NSAIDs, danazol, chlorpromazine, glucocorticoids, ritodrine, salbutamol, terbutaline, anticoagulants, salicylates, disopyramide, chloramphenicol, azole antifungal, quinolones, clarithromycin, cimetidine, corticosteroids, diuretics, phenothiazines, B2 agonists, tetracyclines, oral contraceptives, thyroid hormones, St John's wort.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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