Ceftaroline Fosamil

Cephalosporin · Cephalosporin

Indications

Complicated SSTI, Community-acquired pneumonia.

Dosage

Adults: By IV infusion: 600mg over 60 minutes every 12 hours. Continue for 5-7 days in pneumonia and for 5-14 days in SSTI. Geriatrics: Same as adults. Children: Recommended durations of treatment are 5-14 days for cSSTI and 5-7 days for CAP. 12-18 yrs: Body wt: =33 kg: 600 mg over 60 mins every 12 hrs. Body wt <33kg: 12 mg/kg to a max of 400 mg over 60 mins every 8 hrs. =2yrs-<12 yrs: 12 mg/kg to a max of 400 mg over 60 mins every 8 hrs. Infants =2 mths-<2yrs: 8 mg/kg over 60 mins every 8 hrs. Neonates from birth-<2 mths: 6 mg/kg over 60 mins every 8 hrs.

Administration

Administered by IV infusion over 1 hour. Reconstitution: The contents of ceftaroline fosamil vial should be reconstituted with 20 mL of SWFI. Reconstitution time is less than 2 minutes. Mix gently to reconstitute and check to see that the contents have dissolved completely. Compatibility: Stable in NaCl 0.9%, D5W, D2.5W, NaCl 0.45% and RL. Stability: Vials should be stored refrigerated at 2°C- 8°C (36°F-46°F). Reconstituted solution in the infusion bag should be used within 6 hours when stored at room temperature or within 24 hours when stored under refrigeration at 2°C-8°C (36°F-46°F).

Adverse Effects

Positive coombs test, rash, pruritus, GI upset, raised LFTs, fever, headache, dizziness, phlebitis, infusion site reactions, hypersensitivity reactions, pseudomembranous colitis, haemolytic anaemia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Hypersensitivity to the cephalosporin class of antibacterials. Immediate and severe hypersensitivity (e.g. anaphylactic reaction) to any other type of beta-lactam antibacterial agent (e.g. penicillins or carbapenems). Precautions: Non-severe hypersensitivity to other B-lactams, renal impairment (CrCl < 50ml/mins), history of seizures, pork risk class V and/or pneumonia requiring ventilation at presentation, pneumonia due to MRSA or requiring intensive care, immunocompromised, severe sepsis or septic shock, pneumonia, severe underlying lung disease.

Pharmacokinetics

Metabolism: Converted to bioactive ceftaroline in plasma by phosphatase enzyme; undergoes hydrolysis. Half-life elimination: Preterm neonates <32 wks GA: PNA 3 days: 8.7 ± 2.8 hrs. PNA 10 days: 5 ± 0.9 hrs. Adults: 1-2 hrs, significantly prolonged with renal impairment. Time to peak, serum: IM: Approx. 1 hr. Excretion: Urine (80%-90% as unchanged drug). Faeces (6%).

Brands with this active ingredient

• Ceflaro
• Zinforo

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.