Dothiepin

by Glitz

Active ingredients: Dothiepin, Tricyclic antidepressant (TCAD)

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About Dothiepin

Antidepressant

Uses

Depression, anxiety associated with depression.

How to take it

Adults: 75-150 mg daily in divided doses or as single dose in the evening. Elderly: Initially 50-75 mg daily increasing gradually if necessary under close supervision. Children: Not recommended.

Side effects

Anticholinergic effects (e.g. dry mouth, blurred vision), drowsiness, disturbances of lipid and potency, psychiatric effects, postural hypotension, arrhythmias, allergic skin reactions. Rarely, bone marrow depression, SIADH, hepatitis, jaundice, blood dyscrasias, convulsions.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Recent MI, heart block, arrhythmias, mania, severe hepatic impairment. Porphyria. Precautions: History of epilepsy, glaucoma, prostatic hypertrophy, cardiovascular disorders. Suicidal tendencies. Anaesthesia. Elderly. Withdraw gradually.

Advice

Take with meals. Do not stop taking medication abruptly, gradually lower the dose and then stop. Contact prescriber if there is dizziness, blurred vision, fast heart rate, urinary retention, tremor, blood disorders, low blood pressure, sexual dysfunction or sweating.

Full information on Dothiepin →

Interactions with Dothiepin

With or within 14 days of MAOIs, other antidepressants, CNS depressants, antihypertensives, sympathomimetics, drugs affecting cardiac conduction (e.g. Sotalol), barbiturates.

Tell your pharmacist or doctor about every medicine you take, including herbal products.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.