Dothiepin

Antidepressant · Tricyclic antidepressant (TCAD)

Indications

Depression, anxiety associated with depression.

Dosage

Adults: 75-150 mg daily in divided doses or as single dose in the evening. Elderly: Initially 50-75 mg daily increasing gradually if necessary under close supervision. Children: Not recommended.

Adverse Effects

Anticholinergic effects (e.g. dry mouth, blurred vision), drowsiness, disturbances of lipid and potency, psychiatric effects, postural hypotension, arrhythmias, allergic skin reactions. Rarely, bone marrow depression, SIADH, hepatitis, jaundice, blood dyscrasias, convulsions.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Recent MI, heart block, arrhythmias, mania, severe hepatic impairment. Porphyria. Precautions: History of epilepsy, glaucoma, prostatic hypertrophy, cardiovascular disorders. Suicidal tendencies. Anaesthesia. Elderly. Withdraw gradually.

Interactions

With or within 14 days of MAOIs, other antidepressants, CNS depressants, antihypertensives, sympathomimetics, drugs affecting cardiac conduction (e.g. Sotalol), barbiturates.

Advice to Patient

Take with meals. Do not stop taking medication abruptly, gradually lower the dose and then stop. Contact prescriber if there is dizziness, blurred vision, fast heart rate, urinary retention, tremor, blood disorders, low blood pressure, sexual dysfunction or sweating.

Brands with this active ingredient

• Dothiepin
• Prothiaden

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.