Closip

by Shrooq

Active ingredient: Cycloserine

Packs

About Cycloserine

Antituberculosis Preps

Uses

Adjunctive treatment in pulmonary or extrapulmonary tuberculosis.

How to take it

Adults: Initially 250 mg every 12 hr for 14 days, then administer 500 mg to 1 gm/day in 2 divided doses for 18-24 mth (max daily dose 1 gm). Children: 10-20 mg/kg/day in 2 divided doses up to 1000 mg/day for 18-24 mth.

Side effects

Cardiac arrhythmias. Drowsiness, headache, dizziness, vertigo, seizures, confusion, psychosis, paresis, coma. Rash. Vitamin B12 deficiency. Folate deficiency. Liver enzymes increased. Tremor.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Acute porphyria. Precautions: Epilepsy, depression, anxiety, renal insufficiency.

Advice

Take with or without meals. To prevent abdominal discomfort, take after meals. Contact prescriber if there is acute headache, tremors, skin rash, depression, confusion, nightmares, suicide thoughts, fluid retention, difficulty in breathing, swelling of ankles/hands/feet, unusual weight gain or if there is no improvement in condition until after 2-3 weeks. Avoid alcohol intake during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber.

Full information on Cycloserine →

Interactions with Cycloserine

INH, ethionamide, phenytoin, alcohol.

Tell your pharmacist or doctor about every medicine you take, including herbal products.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.