Zycram

by Al-Habib

Active ingredient: Cyclophosphamide

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About Cyclophosphamide

Cytostatic

Uses

Malignant lymphomas, leukaemias, multiple myeloma, mycosis fungoides, neuroblastoma, ovary adenocarcinoma, retinoblastoma, breast carcinoma.

How to take it

INJECTION: Adults & Children: IV: 40-50 mg/kg in divided doses over 2-5 days, or 10-15 mg/kg for 7-10 days, or 3-5 mg/kg. ORAL: Adults & Children: 1-5 mg/kg/day. IV: May be administered IP, intrapleurally, IVPB, or continuous intravenous infusion, may also be administered slow IVP in doses <1 gm. IV infusions may be administered over 1-24 hours. Doses >500 mg to approximately 2 g may be administered over 20-30 min. To minimize bladder toxicity, increase normal fluid intake during and for 1-2 days after cyclophosphamide dose. Most adult patients will require a fluid intake of at least 2 litre/day. High-dose regimens should be accompanied by vigorous hydration with or without mesna therapy.…

Side effects

Nausea, vomiting, reticule-endothelial suppression, urothelial toxicity, myelosuppression, immunosuppression, impaired sperm production infections, haemolytic uraemic syndrome, mucosal inflammation, alopecia, hepatic dysfunction, fever, asthenia, haematuria, cystitis. Secondary malignancies, cardiac and pulmonary toxicity, renal dysfunction, hyponatraemia.

Pregnancy and breastfeeding

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended. Contraindications: Bladder haemorrhage, acute UTI. Myelosuppression. Acute infection, bone marrow aplasia, acute urothelial toxicity, haemorrhagic cystitis. Precautions: Renal and hepatic impairment. Monitor blood counts. Elderly, debilitated, diabetes. Risk of irreversible infertility.

Advice

Take oral form 1 hour before or 2 hours after meals. To prevent GI upset, take with meals. Swallow whole tablet. Do not take at night. If there is headache, severe vomiting and nasal congestion or cold symptoms, consult prescriber for suitable analgesic, antiemetic and decongestant. Contact prescriber if there is trouble or pain with urination, fast heartbeat, chest pain, palpitations, unusual rash, easy bruising or bleeding, menstrual abnormalities, constant nausea, vomiting, difficulty in breathing, swelling of extremities, unusual fatigue. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Urinate frequently to prevent…

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Interactions with Cyclophosphamide

Radiotherapy, doxorubicin, sulphonylureas, other cytotoxics, other myelosuppressants, oral hypoglycaemics, allopurinol, suxamethonium.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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