Utoral

by Al-Habib

Active ingredient: Fluorouracil

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About Fluorouracil, Inj

Cytostatic

Uses

Palliative management of colon, rectum, breast, stomach & pancreatic carcinomas.

How to take it

Palliative Management of Colon, Rectum, Breast, Stomach & Pancreatic Carcinomas: Adults: Initial: 12 mg/kg/day (up to 800 mg/day) x 4 days, then 6 mg/kg on days 6, 8, 10 & 12. Maintenance: Either repeat initial dose every 30 day or after toxic signs subside, give 10-15 mg/kg/wk as a single dose (up to 1 gm/wk). Children: Not recommended. IV: Formulation may be given orally mixed in water, grape juice, or carbonated beverage. It is generally best to drink undiluted solution, then rinse the mouth. Coca-Cola has been recommended as the “best chaser” for oral fluorouracil. IV: Irritant. Direct IVP injection (50 mg/mL solution needs no further dilution) or by IV Infusion. Toxicity may be reduced…

Side effects

Dermatitis, rash, alopecia, GI upset, leukopenia, myelo-suppression.

Pregnancy and breastfeeding

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended. Contraindications: Depressed bone marrow function, thrombocytopenia, serious infection, major surgery. Precautions: Impaired renal or liver function.

Advice

Contact prescriber if there is nausea, vomiting, abdominal pain, fever, chills, sore throat, pain or burning on urination, vaginal discharge or itching, mouth sores, fatigue, dark stool, blood in stools, unusual bruising or bleeding, change in vision, chest pain, palpitations, difficulty in breathing, mental or emotional changes. Avoid alcohol during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Take small, frequent meals to maintain good nutritional status. Avoid highly crowded places to prevent infection. Avoid direct sunlight, use protective clothing, wear sunscreen and eyewear to prevent photosensitivity.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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