Votrient

by Novartis/Nouveaux

Active ingredient: Pazopanib

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About Pazopanib

Cytostatic

Uses

Advanced renal cell carcinoma, as first line treatment and following cytokine therapy. Advanced soft tissue sarcoma.

How to take it

Adults: 800 mg once daily. Children: Not recommended.

Side effects

Blood dyscrasias, hypothyroidism, decreased appetite, dysgeusia, headache, lethargy, paraesthesia, hypertension, hot flush, epistaxis, GI upset, abnormal hepatic function, hair colour. Change, skin reactions, myalgia, muscle spasms, proteinuria, fatigue, asthaenia, mucosal inflammation, oedema, chest pain, altered LFTs and blood chemistry, weight loss. Cardiac dysfunction, transient ischaemic attack, stroke, myocardial infarction, myocardial ischaemia, bradycardia, haemorrhage, hypertensive crisis, QT-interval prolongation, pulmonary embolism, peripheral neuropathy, menstrual disturbances. Alopecia, hand-foot syndrome, proteinuria, infection, nail disorder, hypophosphataemia, dehydration,…

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe hepatic impairment. Ensure adequate contraception in women of childbearing age. Cerebral or clinically significant haemorrhage or haemoptysis in the past 6 months. Precautions: Renal impairment (CrCl <30 mL/min). Mild to moderate hepatic impairment. Monitor hepatic function before and at least four times weekly for 1st four months of treatment, then monitor periodically. Hypertension; withdraw temporarily if severe and unresponsive to therapy and dose reduction required. History of or risk factors for QT prolongation; monitor ECG and electrolytes. Risk factors for MI, ischaemic…

Advice

Take atleast 1 hour before or 2 hours after meals. Do not chew or crush tablets, swallow whole. If you miss a dose, take it as soon as you remember unless 12 hours are left for the next dose. Do not take double dose. If a surgery is due, inform surgeon about taking this medication because it may need to be discontinued 7 days before surgery. Contact prescriber if there is nausea or vomiting, loss of appetite, dark urine, tiredness, easy bruising or bleeding, pain on right side of the stomach. Do not take grapefruit juice and products containing grapefruit during therapy.

Full information on Pazopanib →

Interactions with Pazopanib

Inducers, inhibitors and substrates of P-glycoprotein, breast cancer resistance protein (BCRP) and CYP3A4. Substrates of UGT1A1 (e.g. irinotecan). Rosuvastatin, grapefruit juice, agents that increase QT interval, lapatinib, pemetrexed, statins, PPIs, H2 antagonists, other drugs that increase gastric pH.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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