Vinblas

by Pharmedic

Active ingredient: Vinblastine

Packs

About Vinblastine

Cytostatic

Uses

See under dosage.

How to take it

Hodgkin's disease/lymphocytic lymphoma/ histiocytic lymphoma/advanced mycosis fungoides/advanced testicular cancer/Kaposi's sarcoma Letterer-Siwe disease/resistant choriocarcinoma/unresponsive breast cancer: Dose IV at weekly intervals. Adults: 1st dose=3.7 mg/m², 2nd dose=5.5 mg/m², 3rd dose=7.4 mg/m², 4th dose=9.25 mg/m², 5th dose= 11.1 mg/m², increase to a max 18.5 mg/m². Children: 1st dose=2.5 mg/m², 2nd dose=3.75 mg/m², 3rd dose=5 mg/m², 4th dose=6.25 mg/m², 5th dose= 7.5 mg/m², increase to a max 12.5 mg/m². Maintenance: Dose is 1 increment smaller than when leucopenia produced. IV: Vesicant. Drug is for IV administration only. Administer vinblastine IV, usually as a slow (2-3 min)…

Side effects

Alopecia, SIADH, diarrhoea, anorexia, severe bone marrow suppression.

Pregnancy and breastfeeding

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended. Contraindications: Bone marrow suppression. Precautions: For IV use only, IT administration may result in death.

Advice

This medication is administered by infusion. Consult prescriber for antiemetic to relieve nausea and vomiting. Report immediately redness/swelling/pain/burning at infusion site. Contact prescriber if there is fever, chills, sore throat, burning on urination, fatigue, muscle pain or weakness, jaw pain or weakness, numbness or tingling in toes or fingers, unusual bruising or bleeding, dark coloured stool, blood in stool, urine or mouth, difficulty in breathing, skin rash, skin itching, unrelieved mouth sores. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Avoid highly crowded places to prevent infection. Do not get vaccinated…

Full information on Vinblastine →

Interactions with Vinblastine

Mitomycin C, CYP3A4 enzyme inhibitors.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.