Vinblastine
Cytostatic · Vinca alkaloid
Indications
See under dosage.
Dosage
Hodgkin's disease/lymphocytic lymphoma/ histiocytic lymphoma/advanced mycosis fungoides/advanced testicular cancer/Kaposi's sarcoma Letterer-Siwe disease/resistant choriocarcinoma/unresponsive breast cancer: Dose IV at weekly intervals. Adults: 1st dose=3.7 mg/m², 2nd dose=5.5 mg/m², 3rd dose=7.4 mg/m², 4th dose=9.25 mg/m², 5th dose= 11.1 mg/m², increase to a max 18.5 mg/m². Children: 1st dose=2.5 mg/m², 2nd dose=3.75 mg/m², 3rd dose=5 mg/m², 4th dose=6.25 mg/m², 5th dose= 7.5 mg/m², increase to a max 12.5 mg/m². Maintenance: Dose is 1 increment smaller than when leucopenia produced.
Administration
IV: Vesicant. Drug is for IV administration only. Administer vinblastine IV, usually as a slow (2-3 min) push, or a bolus (5-15 min) infusion. It is occasionally given as a 24-hour continuous infusion. Reconstitution: Reconstitute to a conc of 1 mg/mL with bacteriostatic water, bacteriostatic NS, SWFI, NS, or D5W; for infusion, may be diluted with 50-1000 mL NS or D5W. Compatibility: Stable in D5W, LR, NS, bacteriostatic water.
Adverse Effects
Alopecia, SIADH, diarrhoea, anorexia, severe bone marrow suppression.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended. Contraindications: Bone marrow suppression. Precautions: For IV use only, IT administration may result in death.
Interactions
Mitomycin C, CYP3A4 enzyme inhibitors.
Advice to Patient
This medication is administered by infusion. Consult prescriber for antiemetic to relieve nausea and vomiting. Report immediately redness/swelling/pain/burning at infusion site. Contact prescriber if there is fever, chills, sore throat, burning on urination, fatigue, muscle pain or weakness, jaw pain or weakness, numbness or tingling in toes or fingers, unusual bruising or bleeding, dark coloured stool, blood in stool, urine or mouth, difficulty in breathing, skin rash, skin itching, unrelieved mouth sores. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Avoid highly crowded places to prevent infection. Do not get vaccinated without consulting prescriber. Avoid direct sunlight, wear sunscreen, proper eyewear and protective clothing to prevent photosensitivity. Take care to prevent injury of toes and fingers. Using soft…
Pharmacokinetics
Metabolism: Hepatic. Half-life elimination: Terminal: Approx. 25 hours. Excretion: Feces (10%); urine (14%).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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