Vesanoid

by Roche

Active ingredient: Tretinoin

Packs

About Tretinoin, Oral

Cytostatic

Uses

With anthracycline-based chemotherapy in acute promyelocytic leukaemia.

How to take it

Adults & Children: 45 mg/m² daily in two divided doses with a meal. Continue treatment until complete remission or up to max 90 days.

Side effects

Retinoic acid syndrome; treat if develops. Thrombosis. Dry skin and mucous membranes, rash, cheilitis, headache, CNS disturbances, intracranial hypertension, visual, hearing and GI disturbances, bone pain, chest pain, raised serum lipids, dyspnoea, asthma-like syndrome, arrhythmia, flushing, oedema, hyperleukocytosis.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Soya or peanut allergy. Precautions: Renal or hepatic impairment. Monitor haematology, coagulation, liver function and serum lipids frequently.

Advice

Take with meals. Do not crush, chew or dissolve capsules. Contact prescriber if there is constant vomiting, diarrhoea, acute stomach pain, unusual bruising or bleeding, difficulty in breathing, changes in vision, unusual weight gain, swelling of extremities, bone pain. Avoid alcohol, foods containing vitamin A and food containing high fat content during treatment. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Avoid wearing contact lenses during therapy to prevent irritation of eyes. Avoid direct sunlight, wear sunscreen, proper eyewear and protective clothing to prevent photosensitivity.

Full information on Tretinoin, Oral →

Interactions with Tretinoin, Oral

Progestogen-only contraceptives, tetracyclines, vit. A, liver enzyme inducers and inhibitors, antifibrinolytics.

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More from Roche

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.