Mestinon

by Roche

Active ingredient: Pyridostigmine bromide

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About Pyridostigmine Bromide

Other CNS Drugs

Uses

Myasthaenia gravis. Paralytic ileus.

How to take it

Adults: Myasthaenia gravis: Usually 300-1200 mg daily in divided doses. Paralytic ileus: 60-240 mg as required. Children: Treatment of Myasthaenia gravis: Neonate, initially 1-1.5 mg/kg, increased gradually to max 10 mg, repeated throughout the day, give 30-60 minutes before feeds; 1 mth-12 yr, initially 1-1.5 mg/kg/day, increased gradually to 7 mg/kg/day in 6 divided doses; usual total daily dose 30-360 mg; 12-18 yr, 30-120 mg, repeated throughout the day; usual total daily dose 300-600 mg. Consider immunosuppressant therapy if total daily dose exceeds 360 mg, down-regulation of acetylcholine receptors possible if total daily dose exceeds 450 mg.

Side effects

Nausea, salivation, diarrhoea, colic.

Pregnancy and breastfeeding

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Contraindications: Intestinal or urinary obstruction. Precautions: Bronchial asthma, cardiac disease, vagotonia, epilepsy, Parkinsonism, bradycardia, recent coronary occlusion, hypotension, peptic ulcer. Renal disease.

Advice

Take with meals. Take extended release tablets at bedtime. Do not chew or crush extended release tablets. Contact prescriber if there is acute headache, dizziness or depression, lack of sleep, unrelieved diarrhoea, increased fatigue, stomach discomfort, increased salivation/tearing/sweating/urination, chest pain or palpitations, flushing of skin, change in vision, blurred vision, increased muscle/body/joint pain, difficulty in breathing, wheezing. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Change position slowly from sitting or lying to standing. Carry medical identification card mentioning patient's condition and names…

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Interactions with Pyridostigmine Bromide

Depolarising muscle relaxants, cyclopropane, halothane, antimuscarinics.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.