Urofix

by Allmed Labs

Active ingredient: Urokinase

Packs

About Urokinase

Anticoagulant/Antiplatelet

Uses

To maintain patency of thrombosed intravascular catheters and cannulae, deep vein thrombosis, pulmonary embolism, peripheral vascular occlusion.

How to take it

Deep vein thrombosis: By IV infusion, initially 4400 units/kg in 15 mL sodium chloride 0.9% over 10 min, followed by 4400 units/kg/hr for 12-24 hr. Pulmonary embolism: By IV infusion, initially 4400 units/kg in 15 mL sodium chloride 0.9% over 10 min, followed by 4400 units/kg/hr for 12 hr or by injection into pulmonary artery, initially 15000 units/kg subsequent doses adjusted according to response; max 3 doses in 24 hr. Occluded catheters and cannulas: By injection directly into catheter or cannula, 5000-25000 units dissolved in suitable volume of sodium chloride 0.9% to fill the catheter or cannula lumen; leave for 20-60 min then aspirate the lysate, repeat if necessary. Peripheral…

Side effects

Local irritation, bleeding and haemorrhagic complications, pyrexia, haematuria, embolic episodes, cholesterol embolism, allergic reactions.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Recent bleeding following surgery, cerebrovascular bleeding, severe hypertension, severe hepatic or renal impairment, immediate postpartum period. Precautions: Peptic ulcer or risk of GI bleeding, recent repeated intravascular or intracardiac puncture, recent cardiopulmonary resuscitation.

Advice

Contact prescriber if there is chest pain; palpitations; irregular heartbeat; unusual bruising or bleeding; muscle pain; redness, swelling, oozing at infusion site; acute headache; joint pain; vision changes or respiratory difficulty. To prevent bleeding, use soft toothbrush, floss with waxed floss, use electric razor, avoid scissors or sharp knives and harmful activities. Take strict bed rest to avoid injury. If bleeding occurs, report immediately and apply pressure to bleeding spot until bleeding stops completely.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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