Sorolan

by Specific

Active ingredients: Methoxsalen, Methoxsalen (Meladinine)

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About Methoxsalen

Antipsoriasis

Uses

Psoriasis, idiopathic vitiligo (in conjunction with UV radiation or photosensitizing agent).

How to take it

ORAL: Take with milk or after food as a single dose, or in 2 divided doses, approx 30 min apart to minimize GI side effects. Idiopathic vitiligo: Adults & Children: Above 12 yr: 20 mg/day 2-4 hr before exposure to UVA or sunlight. Therapy should be on alternate days & never on 2 consecutive days. Max dose: 0.6 mg/kg. Psoriasis: Adults: 10-70 mg, 1.5-2 hr before exposure to UVA, administered 2-3 times wkly. TOPICAL: Vitiliginous lesions: Adults: The soln/cream after dilution to 0.1% or 0.01% applied once wkly for 6-9 mth. Surrounding skin should be protected by an opaque screen, the treated area should be exposed to UVA after waiting up to 2 hr. After exposure the lesions should be washed…

Side effects

Oedema, hypotension, nervousness, vertigo, depression, painful blistering, burning, pruritus, hypo-pigmentation, rash, cheilitis, erythema, itching, nausea, loss of muscle coordination.

Pregnancy and breastfeeding

Contraindications: Diseases associated with light sensitivity (lupus erythematosus, porphyria). Hypertension, heart, liver or kidney failure. Precautions: Protect eyes & skin against complementary sun exposure after controlled UV irradiation. Monitor patients on possible long-term risks of photo-chemotherapy e.g. skin aging, changes in pigmentation, risk of basal cell epithelioma & cataract.

Full information on Methoxsalen →

Interactions with Methoxsalen

Photosensitizing agents e.g. anthracin, coal tar, griseofulvin, phenothiazine, nalidixic acid, halogenated salicylamide, sulphonamides, tetracycline, thiazides, organic dyes.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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