Rezkew

by LCI

Active ingredient: Resmetirom

Packs

About Resmetirom

Cholagogue & Hepatic Preps

Uses

Treatment of noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis).

How to take it

Adults: Body wt <100 kg: 80 mg once daily. =100 kg: 100 mg once daily. Children: Not recommended.

Side effects

Diarrhoea, nausea, vomiting, dizziness, pruritus, abdominal pain, constipation.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Decompensated cirrhosis. Moderate to severe hepatic impairment (Child-Pugh Class B or C). Precautions: Monitor patients during treatment for elevation in liver tests and for the development of liver-related adverse reactions. Acute cholecystitis, cholelithiasis. Elderly.

Advice

Take with or without meals. Immediately report any signs or symptoms of severe liver injury (e.g. fatigue, nausea, vomiting, right upper quadrant pain or tenderness, jaundice, fever, rash) or symptoms of gallbladder adverse reactions, including cholelithiasis, cholecystitis, and obstructive pancreatitis (gallstone).

Full information on Resmetirom →

Interactions with Resmetirom

Strong or moderate CYP2C8 inhibitors (e.g. gemfibrozil, clopidogrel etc); avoid. OATP1B1 and OATP1B3 inhibitors (e.g. cyclosporine); avoid. CYP2C8 substrates. Atorvastatin, Pravastatin, Rosuvastatin and Simvastatin.

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More from LCI

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.