Paloxi

by Himmel

Active ingredient: Palonosetron

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About Palonosetron

Antiemetic & Gastroprokinetic

Uses

Prevention of chemotherapy-induced nausea and vomiting. Prevention of postoperative nausea and vomiting.

How to take it

Prevention of Chemotherapy-induced nausea and vomiting: IV: Adults: 0.25 mg as a single IV dose administered over 30 seconds. Administer dose 30 mins before the initiation of chemotherapy. Children: <1 mth: Not recommended. 1 mth-18 yrs: 20 mcg/kg infused over 15 mins, beginning 30 mins before chemotherapy; not to exceed 1.5 mg/dose. Prevention of Postoperative nausea and vomiting: Adults: IV: 0.075 mg as a single IV dose administered over 10 seconds immediately before the induction of anaesthesia. Children: Not recommended. Flush the infusion line with NS before and after administration of Palonosetron HCl injection. Inspect inj visually for particulate matter and discoloration before…

Side effects

Hyperkalaemia, metabolic disorders, hypocalcaemia, anorexia, hyperglycaemia, decreased appetite, anxiety, euphoric mood, headache, dizziness, somnolence, insomnia, paraesthesia, hypersomnia, peripheral sensory neuropathy, eye irritation, amblyopia, motion sickness, tinnitus. Tachycardia, bradycardia, extrasystoles, myocardial ischaemia, sinus tachycardia, sinus arrhythmia, supraventricular extrasystoles, hypotension, hypertension, vein discolouration, vein distended, dermatitis, pruritic rash, arthralgia, urinary retention, glycosuria, asthaenia, pyrexia, fatigue, feeling hot, influenza like illness.

Pregnancy and breastfeeding

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Contraindications: Coadministration with apomorphine. Precautions: Congenital long QT syndrome or other factors that may prolong QT interval. For chemotherapy, the drug should follow a specific schedule, and not be administered as needed.

Advice

Contact prescriber/nurse right away if you experience hives, swelling in face, trouble in breathing, chest pain, agitation, hallucinations, confusion, coma, fast/unusual heartbeat, dizziness, sweating, flushing, fever, tremors, stiffness in muscles, muscle twitching, loss of coordination, seizures, nausea, vomiting, diarrhoea.

Full information on Palonosetron →

Interactions with Palonosetron

Serotonergic drugs including SSRIs, SNRIs, MAO inhibitors, lithium, tramadol, methylene blue IV and mirtazapine (avoid).

Tell your pharmacist or doctor about every medicine you take, including herbal products.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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