Nitrop

by Graton

Active ingredient: Sodium nitroprusside

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About Sodium Nitroprusside

Cardiac Therapy

Uses

Hypertensive crisis, controlled hypotension in anaesthesia, acute or chronic heart failure.

How to take it

Adults: Hypertensive crisis: By IV infusion, initially 0.5-1.5 mcg/kg/min, then increased in steps of 500 nanograms/kg/min every 5 min within range 0.5-8 mcg/kg/min (lower doses in patients already receiving other antihypertensives); stop if response unsatisfactory with max dose in 10 min. Lower initial dose of 300 nanograms/kg/min has been used. Maintenance of blood pressure at 30-40% lower than pretreatment diastolic blood pressure, 20-400 mcg/min (lower doses for patients being treated with other antihypertensives). Controlled hypotension in surgery: By IV infusion, max 1.5 mcg/kg/min. Heart failure: By IV infusion, initially 10-15 mcg/min, increased every 5-10 min as necessary; usual…

Side effects

Associated with over rapid reduction in blood pressure (reduce infusion rate); headache, dizziness, nausea, abdominal pain, perspiration, palpitation, anxiety, retrosternal discomfort; occasionally reduced platelet count, acute transient phlebitis.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Severe vitamin B12 deficiency; Leber's optic atrophy; compensatory hypertension. Precautions: Hypothyroidism, hyponatraemia, ischaemic heart disease, impaired cerebral circulation, elderly; hypothermia; monitor blood pressure and blood-cyanide concentration and if treatment exceeds 3 days, also blood-thiocyanate concentration; avoid sudden withdrawal, terminate infusion over 15-30 min; protect infusion from light.

Advice

Contact prescriber immediately if there is chest pain, burning or pain at infusion site. Change position slowly to minimize dizziness.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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