Gefiton

by Graton

Active ingredient: Gefitinib

Packs

About Gefitinib

Cytostatic

Uses

Locally advanced or metastatic non-small cell lung cancer with activating mutations of EGFR-TK.

How to take it

Adults: 250 mg once daily. Children: Not recommended.

Side effects

Anorexia, GI upsets, interstitial lung disease (discontinue), haemorrhage, eye infections, dry eye, dry mouth, abnormal LFTs, skin reactions, nail disorders, alopecia, raised creatinine, proteinuria, cystitis, asthaenia, pyrexia. Reports of GI perforation.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Precautions: Moderate to severe hepatic impairment, renal impairment (CrCl = 20 mL/min), CYP2D6 poor metabolisers. Risk factors for GI perforation. Monitor liver function. Interrupt treatment and evaluate patient who develop unexplained pulmonary symptoms. Advise patients to report eye symptoms or severe or persistent GI upset or anorexia.

Advice

Take with or without meals. Disperse tablet in half glass of non-carbonated water. Do not take with any other liquid. Do not crush it. Drop tablet in water, and stir for about 10 minutes. Drink it immediately. Rinse the glass with another half glass of water and drink. Liquid may also be administered through nasogastric tube. Do not take antacids 2 hours before or after taking this medication. Contact prescriber if there is chest pain, cough, difficulty in breathing, wheezing, severe constant diarrhoea, skin rash, eye pain, change in vision, eye infection, joint pain, weakness. Periodic laboratory tests are required during treatment. Take sufficient amount of fluids (2-3 litres per day) to…

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Interactions with Gefitinib

Phenytoin, carbamazepine, rifampicin, barbiturates, St. John's Wort and other CYP3A4 inducers. Azole antifungals, macrolides, protease inhibitors and other CYP3A4 inhibitors. Warfarin, PPIs, H2 antagonists, antacids, vinorelbine.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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