Hydrourea

by Pharmedic

Active ingredient: Hydroxyurea

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About Hydroxyurea

Cytostatic

Uses

Chronic myeloid leukaemia; melanoma; recurrent, metastatic or inoperable carcinoma of the ovary. Sickle-cell disease.

How to take it

Adults: Solid Tumours: Intermittent: 80 mg/kg as a single dose every 3 day. Continuous: 20-30 mg/kg every day. Resistant CML: 20-30 mg/kg every day. Sickle-cell disease: Initially 15 mg/kg daily, increased in steps of 2.5-5 mg/kg daily, dose to be increased every 12 wks according to response. Usual dose: 15-30 mg/kg daily, max 35 mg/kg/day.

Side effects

Oedema, drowsiness, hallucinations, headache, dizziness, fever, chills, pruritus, rash, hyperuricaemia, GI upsets, dysuria, myelosuppression, liver enzyme elevation, peripheral neuropathy, renal impairment, dyspnoea, pulmonary fibrosis.

Pregnancy and breastfeeding

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended. Contraindications: Marked bone marrow depression; severe anaemia. Precautions: Haematological monitoring including bone marrow; monitor hepatic and renal function; recent X-ray or cytostatic therapy; pre-menopausal women.

Advice

Take as advised by prescriber. Capsule contents may be mixed with a glass of water and taken. Contact prescriber if there is skin rash, irritation, redness, skin sores, mouth sores, abdominal pain, severe nausea, vomiting, diarrhoea, constipation, difficulty in urination, severe fever or chills, increased confusion, depression, hallucinations, seizures, lethargy, unusual fatigue, unhealed sores, white plaques in mouth, vaginal discharge, easy bruising or bleeding, blood in vomit/stool/urine, unusual weakness, muscle tremors. Avoid highly crowded places to prevent infection. Do not get vaccinated without consulting prescriber.

Full information on Hydroxyurea →

Interactions with Hydroxyurea

Cytarabine, didanosine, stavudine.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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