H-Done

by Heal

Active ingredient: Domperidone

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About Domperidone

Antiemetic & Gastroprokinetic

Uses

Epigastric sense of fullness, upper abdominal distention, regurgitation. Nausea and vomiting.

How to take it

ORAL: Adults: All indications: 10-20 mg orally 3-4 times daily before meals; max 80 mg daily. Re-evaluate need for continued treatment after 4 wk. Children: Only Nausea & Vomiting: 0.25-0.5 mg/kg body-wt, 3-4 times daily; max 2.4 mg/kg daily. INJECTION: Adults: With chemotherapy 1-40 mg IV (1 mg/kg IV have been used). See literature. Children: Not recommended. RECTAL: Adults & Children: Over 12 yr and body weight over 35 kg: 60 mg twice daily. Children: Body weight 15-35 kg (nausea and vomiting only): 30 mg twice daily; under 15 kg, not recommended.

Side effects

Rarely, GI upset, raised serum prolactin, ventricular arrhythmia, sudden cardiac death.

Pregnancy and breastfeeding

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Prolactinoma, GI haemorrhage, perforation or obstruction, hepatic impairment, cardiac conditions. Precautions: Renal impairment, electrolyte disturbances. Elderly (>60 years)

Advice

Take oral form 15-30 minutes before meals.

Full information on Domperidone →

Interactions with Domperidone

Ketoconazole, ritonavir, erythromycin, other potent CYP3A4 inhibitors or drugs that prolong QT interval.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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