Domperidone

Antiemetic & Gastroprokinetic · Antidopaminergic

Indications

Epigastric sense of fullness, upper abdominal distention, regurgitation. Nausea and vomiting.

Dosage

ORAL: Adults: All indications: 10-20 mg orally 3-4 times daily before meals; max 80 mg daily. Re-evaluate need for continued treatment after 4 wk. Children: Only Nausea & Vomiting: 0.25-0.5 mg/kg body-wt, 3-4 times daily; max 2.4 mg/kg daily. INJECTION: Adults: With chemotherapy 1-40 mg IV (1 mg/kg IV have been used). See literature. Children: Not recommended. RECTAL: Adults & Children: Over 12 yr and body weight over 35 kg: 60 mg twice daily. Children: Body weight 15-35 kg (nausea and vomiting only): 30 mg twice daily; under 15 kg, not recommended.

Adverse Effects

Rarely, GI upset, raised serum prolactin, ventricular arrhythmia, sudden cardiac death.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Prolactinoma, GI haemorrhage, perforation or obstruction, hepatic impairment, cardiac conditions. Precautions: Renal impairment, electrolyte disturbances. Elderly (>60 years)

Interactions

Ketoconazole, ritonavir, erythromycin, other potent CYP3A4 inhibitors or drugs that prolong QT interval.

Advice to Patient

Take oral form 15-30 minutes before meals.

Pharmacokinetics

Absorption: Rapid. Metabolism: Hepatic (rapid and extensive). Bioavailability: Absolute bioavailability: Oral: 15%. IM: 90%. Half-life elimination: 7.5 hrs. Hepatic impairment: 15-23 hrs. Renal impairment: 7.4-20.8 hrs. Time to peak, plasma: 1 hr after dosing. Excretion: Urine (30% of an oral dose). Faeces (66%).

Brands with this active ingredient

• Act-On
• Almedon
• Ambrilium
• Avifix
• Bylium
• Convel-V
• Deflux
• Do-one
• Dolium
• Dom-D
• Domact
• Domcelium
• Dome-One
• Domec
• Domflash

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.