Gesic

by Unexo

Active ingredient: Buprenorphine

Packs

About Buprenorphine

Narcotic Analgesic

Uses

Moderate to severe pain.

How to take it

Adults: Injection: 0.3-0.6 mg by IM or slow IV inj six or eight hourly. Tablets: 1-2 sublingually six to eight hourly or as required. Patch: Chronic pain (moderate to severe): Each patch is intended to be worn for 7 days. Apply patch to a hairless or nearly hairless skin site. For opioid experience patients: 7.5 mcg/hr, 10 mcg/hr, 15 mcg/hr and 20 mcg/hr. Max: 20 mcg/hr. For opioid naive patients: Initiate with a 5 mcg/hr patch. Dose adjustments may be made in 5 mcg/hr, 7.5 mcg/hr, or 10 mcg/hr increments by using no more than two patches of the 5 mcg/hr, 7.5 mcg/hr, or 10 mcg/hr. Max: 20 mcg/hr. For cessation of therapy, use a gradual downward titration of the dose every 7 days to prevent…

Side effects

Drowsiness, nausea, dizziness, sweating, erythema, pruritus, rash, GI upset, dry mouth, anorexia, headache, tremor, insomnia, confusion, depression, anxiety, paraesthesia, dyspnoea, orthostatic hypotension, oedema, fatigue, asthenia, miosis, respiratory depression, vasodilatation, chest pain.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Opioid dependence, severe respiratory or hepatic insufficiency, Myasthaenia gravis. Delirium tremens. Precautions: Narcotic dependence or previous large doses of narcotics. Impaired respiratory or hepatic function. Acute alcohol intoxication, history of seizures, head injury, shock, impaired consciousness, raised intracranial pressure or intracranial lesions, toxic psychosis, fever, prostatic hypertrophy, urinary tract obstruction, biliary tract disorders, hypothyroidism. Elderly or debilitated patients.

Advice

Do not swallow sublingual tablets. Place tablet under tongue and let it dissolve. If more than two tablets do not fit in mouth, place only two tablets at a time and let them dissolve. If you are self-administering injection of this medication, follow directions for administration and disposal of needles as prescribed. Contact prescriber if there is difficulty in breathing, unrelieved nausea or vomiting, unusual weakness, increased sleepiness, chest pain, fast heartbeat, palpitations Avoid alcohol during therapy. Do not take OTC medications especially tranquilizers, sedatives, antihistamines, pain medications without consulting prescriber. Change position slowly when rising from sitting or…

Full information on Buprenorphine →

Interactions with Buprenorphine

MAOIs or CNS depressants, alcohol, benzodiazepines, inhibitors or inducers of CYP3A4, hepatotoxic drugs.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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