Amotrip

by Pharmedic

Active ingredients: Amitriptyline, Tricyclic antidepressant (TCAD)

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About Amitriptyline

Antidepressant

Uses

Depression in adults. Enuresis in children.

How to take it

Adults: Usually 75 mg daily in divided doses increasing if required to 150 mg daily. Maintenance, 50-100 mg daily usually as a single dose at bedtime. Elderly: 50 mg daily in divided doses or as a single dose at bedtime. Children: Depression: 16-18 yr, 10-25 mg 3 times daily (total daily dose may alternatively be given as a single dose at bedtime) increased gradually as necessary to 150-200 mg daily.

Side effects

Anticholinergic effects, (e.g. dry mouth, blurred vision). Tinnitus, confusion, aggression, decreased libido, agitation, somnolence, dizziness, dysarthria, attention disturbance, dysgeusia, paraesthesia, palpitations, drowsiness, headache, tremor, ataxia, seizures, movement disorders, dyskinesias. Cardiovascular effects, e.g. hypotension, tachycardia, syncope, conduction disturbances, arrhythmias, GI upset, taste disturbance. Blood dyscrasias, sweating, allergic skin reactions, weight changes, testicular swelling, gynaecomastia, changes in blood sugar concentrations, hyponatraemia. Behavioural disturbances. Hepatic impairment, jaundice.

Pregnancy and breastfeeding

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Arrhythmias (particularly heart block), recent MI, coronary artery insufficiency, severe liver disease, mania. Porphyria. Precautions: Hepatic impairment (contraindicated if severe). History of epilepsy, urinary retention, glaucoma, or increased intra-ocular pressure, prostatic hypertrophy, risk factors for narrow angle glaucoma, increased IOP, pyloric stenosis, paralytic ileus, diabetes. Cardiovascular disorders, hyperthyroidism; monitor carefully. Pheochromocytoma. History of mania or psychosis, concurrent ECT. Anaesthesia, Reports of QT prolongation and arrhythmia. Monitor for suicidal…

Advice

Take with or without meals immediately before bedtime. Contact prescriber if there is headache, agitation, change in memory, lack of sleep, nervousness, restlessness, change in vision, chest pain, palpitations, irregular heartbeat, muscle cramps, weakness, tremors, rigidity, ringing in ears. Empty bladder before taking medication. Limit alcohol and caffeine intake. Avoid taking grapefruit juice. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Change position slowly from sitting or lying to standing. Avoid direct sunlight. Use sunscreen, wear proper clothing and eyewear to prevent photosensitivity. On start of therapy or…

Full information on Amitriptyline →

Interactions with Amitriptyline

With or within 14 days of MAOIs. Other antidepressants, St. John's Wort, tramadol, drugs that prolong the QT interval (e.g. antiarrhythmics), moxifloxacin, anticonvulsants, diltiazem, verapamil, other antihypertensives, antipsychotics, sotalol, dopaminergics, artemether/lumefantrine, sibutramine, anticholinergics, sympathomimetics, oral anticoagulants, cimetidine, adrenergic neuron blockers (e.g., clonidine), diuretics, SSRIs, tramadol, azole antifungals, terbinafine, alcohol, CYP2D6 inhibitors, oral contraceptives, rifampicin, linezolid, disulfiram.

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Compiled by Healify Pharmacy from published drug references. How we compile it →

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