Vonoprazan
Antipeptic Ulcerant · Potassium-competitive acid blocker
Indications
Gastric ulcer, duodenal ulcer, reflux oesophagitis. Maintenance treatment of reflux oesophagitis, prevention of recurrence of gastric ulcer or duodenal ulcer during NSAIDs administration. Adjunct to H. pylori eradication.
Dosage
Adults: Gastric ulcer: 20 mg once daily for not more than 8 wks. Duodenal ulcer: 20 mg once daily for not more than 6 wks. Reflux/erosive oesophagitis: 20 mg once daily for not more than 4 wks. If needed, may be continued for up to 8 wks. Maintenance: 10 mg once daily. If needed, may be increased up to 20 mg once daily. Prevention of recurrence of gastric or duodenal ulcer during NSAID administration: 10 mg once daily. Adjunct to H. pylori eradication: 3-drug regimen twice daily for 7 days: 20 mg of Vonoprazan, 750 mg of Amoxicillin and 200 mg of Clarithromycin. Dose of clarithromycin may be increased if required. However, do not exceed dosage more than 400 mg/dose twice daily. Alternatively, 20 mg of Vonoprazan, 750 mg of Amoxicillin and 250 mg of Metronidazole.
Adverse Effects
Diarrhoea, constipation, nausea, abdominal discomfort, taste abnormality, skin rash.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Precautions: Hepatic impairment, renal impairment. Elderly.
Interactions
Avoid with drugs which depend on acidic gastric pH for absorption (e.g. atazanavir, rilpivirine, nelfinavir). Itraconazole, digoxin, tyrosine kinase inhibitors (e.g. gefitinib, nilotinib).
Advice to Patient
Take with or without meals.
Pharmacokinetics
Absorption: Rapidly absorbed from the GI tract. Metabolism: Hepatic. Half-life elimination: Approx. 6-8.8 hrs. Time to peak, plasma: Within 2 hrs. Excretion: Urine (approx. 67%). Faeces (31%).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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