Vitamin B6
Other Vitamins · Vitamin
Indications
Vitamin B6 deficiency state. Isoniazid-induced or penicillamine or hydralazine or cycloserine induced neuropathy. Idiopathic sideroblastic anaemia. Premenstrual syndrome.
Dosage
ORAL: Deficiency states: Adults: 20-50 mg up to 3 times daily for 3 wk. Isoniazid-induced or penicillamine or hydralazine or cycloserine induced neuropathy: Adults: Prophylaxis, 10 mg daily (or 20 mg daily if suitable product not available); treatment, 50 mg three times daily. Idiopathic sideroblastic anaemia: Adults: 100-400 mg daily in divided doses. Children: Not recommended. INJECTION: Dietary Deficiency states: Adults: IM or IV the dose is 10 to 20 mg daily for 3 wk. Deficiencies due to Isoniazid: Adults: 100 mg daily for 3 wk followed by a 30 mg maintenance dose daily. Children: Not recommended.
Adverse Effects
Sensory neuropathy reported with high doses given for extended periods.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Hypersensitivity. Precautions: Dependence and withdrawal may occur with daily doses of 200 mg or more. Uses in premenstrual syndrome has not been established scientifically.
Interactions
Levodopa, phenobarbital, phenytoin.
Advice to Patient
Take with meals. Do not chew or crush tablets, swallow whole. Contact prescriber if there is persistent burning or pain at injection site. Do not exceed recommended dietary intake of vitamin B6 (vitamin B6 is present in red meat, bananas, potatoes, yeast, lima beans and whole grain cereals).
Pharmacokinetics
Absorption: Oral: Well absorbed. Metabolism: Hepatic. Half-life elimination: Biologic: 15-20 days. Excretion: Urine.
Unlicensed Use
Adults: Premenstrual syndrome: 50-100 mg daily. Children: Metabolic diseases including cystathioninuria and homocystinuria: Orally. Neonate, 50-100 mg 1-2 times daily; 1 mth-18 yr, 50-250 mg 1-2 times daily. Treatment of isoniazid-induced neuropathy: Orally. Neonate, 5-10 mg daily; 1 mth-12 yr, 10-20 mg 2-3 times daily; 12-18 yr, 30-50 mg 2-3 times daily. Prevention of isoniazid-induced neuropathy: Orally. Neonate, 5 mg daily; 1 mth-12 yr, 5-10 mg daily; 12-18 yr, 10 mg daily. Prevention of penicillamine-induced neuropathy in Wilson’s disease: Orally. 1-12 yr, 5-10 mg daily; 12-18 yr, 10 mg daily. Pyridoxine-dependent seizures: Orally or by IV injection. Neonate, Initial test dose 50-100 mg by IV injection, may be repeated; if responsive followed by an oral maintenance dose of 50-100 mg once daily, adjusted as necessary; 1 mth-12 yr, Initial test dose 50-100 mg daily; if responsive…
Brands with this active ingredient
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