Vildagliptin

Hypoglycaemic excluding Insulin · Dipeptidyl peptidase-4 inhibitor

Indications

Type 2 diabetes mellitus (in combination with metformin or with a sulfonylurea or with pioglitazone).

Dosage

Adults: In combination with metformin or pioglitazone, 50 mg twice daily; in combination with a sulfonylurea, 50 mg daily in the morning. Children: Not recommended.

Adverse Effects

Bullous and exfoliative skin lesions. Monotherapy: Dizziness. With metformin: Tremor, headache, dizziness, nausea, hypoglycaemia. With a sulfonylurea: Tremor, headache, dizziness, asthaenia, hypoglycaemia. With a glitazone: Wt gain, peripheral oedema. With insulin: Headache, hypoglycaemia, chills, GI upset.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Diabetic ketoacidosis, hepatic impairment, CHF. Precautions: Elderly; monitor liver function; heart failure (avoid if moderate or severe). Moderate to severe renal impairment. Risk of pancreatitis; advise patient of symptoms, discontinue if suspected.

Interactions

ACE inhibitors.

Advice to Patient

Take with or without meals.

Pharmacokinetics

Absorption: Rapidly absorbed from the GI tract. Metabolism: Renal. Bioavailability: 85%. Half-life elimination: Oral: 3 hrs. IV inj: 2 hrs. Time to peak, plasma: 1.7 hrs. Excretion: Urine (85%). Faeces (15%).

Brands with this active ingredient

• Aglip
• Altin
• Bygliv
• Galvecta
• Galvus
• Galza
• Glipten
• Glitavil
• Insutol
• Liptin
• Litidik
• Oritide
• Valiant
• Veld
• Velon

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.