Trimethoprim and Sulfadiazine

Trimethoprim & Combinations · Folic acid inhibitor/Sulphonamide

Indications

Infections caused by gram-positive and gram-negative organisms.

Dosage

DS Tab: Adults: 1 tab twice daily. Tab: Adults: 2 tab twice daily. Susp: Adults: 20 mL twice daily. Children: 6 mth-5 yr, 5 mL; 5-12 yr, 10 mL. Both twice daily.

Adverse Effects

Nausea. Glossitis, rash, hyperkalaemia. Blood dyscrasias, folate deficiency.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Neonates. Severe renal or hepatic insufficiency. Precautions: Renal impairment. Severe allergy or asthma, folate or G6PD deficiency. Porphyria. Perform monthly blood count during long term therapy or in elderly or folate deficient; consider folate supplement. Discontinue if rash develops. Maintain adequate urinary output. Monitor serum potassium and sodium in those at risk of hyperkalaemia or hyponatraemia. Elderly.

Interactions

Folate inhibitors, anticoagulants, phenytoin, hypoglycaemics, cyclosporin, procainamide, amantadine, lamivudine, thiazide, pyrimethamine, digoxin.

Pharmacokinetics

TRIMETHOPRIM: Absorption: Oral: Rapidly and almost completely absorbed from the GI tract. Metabolism: Hepatic. Half-life elimination: Adults: 8-10 hrs. Less in children. Prolonged in neonates and in patients with renal impairment. Time to peak, plasma: 1-4 hrs. Excretion: Urine (40%-60%). Faeces. (small amounts). SULPHADIAZINE: Absorption: Readily absorbed from the GI tract. Metabolism: Hepatic (metabolized partially). Half-life elimination: 7-12 hrs. Prolonged in renal impairment. Time to peak, plasma: 3-6 hrs. Excretion: Urine.

Brands with this active ingredient

• Antrima
• Penetrin

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.