Tofisopam

Tranquilizer, Sedative/Hypnotic · Benzodiazepine

Indications

Anxiety.

Dosage

Adults: 50 mg three times daily; up to 300 mg daily. Children: Not recommended.

Adverse Effects

Drowsiness and light headedness, which may continue into the following day. Muscle weakness, ataxia, confusion, vertigo, GI upset, hypotension, visual disturbance, rash, impaired alertness and dexterity, headache, urinary pretension, changes in libido. Rarely blood disorder, jaundice, respiratory depression, abnormal psychological reactions. Paradoxical reactions, anterograde amnesia. Dependence.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Acute pulmonary insufficiency, respiratory depression, sleep apnoea, phobic or obsessional state, chronic psychosis, unstable Myasthaenia gravis. Severe hepatic impairment. As monotherapy to treat depression or anxiety associated with depression. Precautions: Chronic pulmonary insufficiency, Myasthaenia gravis, renal impairment, mild to moderate hepatic impairment, history of drugs or alcohol abuse, personality disorders, Elderly, avoid long-term use. Withdraw gradually.

Interactions

Alcohol, CNS depressants, anticonvulsants, CYP3A4 inhibitors or inducers (e.g. cimetidine, rifampicin).

Advice to Patient

Take last dose before 5 pm to avoid sleep disturbances.

Pharmacokinetics

Absorption: Rapid. Metabolism: Hepatic. Half-life elimination: 6-8 hrs. Time to peak, plasma: 1-1.5 hrs.

Brands with this active ingredient

• Grandaxin

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.