Tofacitinib
Anti-rheumatic, Systemic · Janus associated kinase inhibitor
Indications
Rheumatoid arthritis.
Dosage
Adults: 5 mg twice daily. Children: Not recommended.
Adverse Effects
Hypertension, headache, diarrhoea, UTI, increase ALT, increase creatinine, upper RTI, nasopharyngitis, serious infection, abdominal pain, anaemia, dehydration, drug induce liver injury, dyspepsia, dyspnoea, erythema, gastritis, hepatic steatosis, lymphocytopenia, musculoskeletal pain, neutropenia, peripheral edema, pruritus, pyrexia, rash, sinus congestion, tendonitis, tuberculosis, vomiting.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Severe hepatic impairment, live vaccination, tuberculosis, serious infections, lymphoma. Precautions: Patients who have been exposed to tuberculosis, with history of serious or opportunistic infection, patients who live in or travel to/from areas of endemic mycoses (blastomycosis, coccidioidomycosis, histoplasmosis). Elderly patients. Patients at increased risk for gastrointestinal perforation (e.g. history of diverticulitis).
Interactions
BCG, CYP3A4 inducers, natalizumab, tacrolimus, leflunomide, fluconazole, denosumab, dasatinib, ivacaftor, sitaxsentan, mifepristone, roflumilast, pimecrolimus.
Advice to Patient
Take with or without meals. Contact prescriber if there is severe tiredness, yellowing of skin or eyes, loss of appetite, fever, chills, vomiting, dark coloured stool, abdominal upset, muscle pain, dark urine, skin rash.
Pharmacokinetics
Absorption: Conventional tab: Rapidly and well absorbed. Bioavailability: 74%. Metabolism: Hepatic. Half-life elimination: Conventional tab, oral soln: Approx. 3 hrs. Extended-release tab: Approx. 6-8 hrs. Time to peak, plasma: Conventional tab, oral soln: 0.5-1 hr. Extended-release tab: 4 hrs. Excretion: Mainly via urine (30%)
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.