Tenoxicam
Anti-rheumatic, Systemic · Cox-2 inhibitor
Indications
Osteoarthrosis, rheumatoid arthritis.
Dosage
Adults: 1 tab/cap daily. Children: Not recommended.
Adverse Effects
Drowsiness. GI upset, oedema, headache, rashes, blood dyscrasias, raised liver enzymes, visual disturbances, hypersensitivity reactions, aplastic anaemia, haemolytic anaemia, hepatitis, jaundice, nephrotoxicity. Rarely, vesiculo-bullous reactions, vasculitis.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Caution advised or effect undetermined. Contraindications: History of, or active peptic ulcer, Gl bleeding, gastritis. Aspirin/anti-inflammatory induced allergy. Severe hepatic or renal impairment. Precautions: Hepatic, renal or cardiac impairment (monitor on long term therapy), mild to moderate heart failure, hypertension, asthma, surgery. Use lowest effective dose for shortest duration. Elderly.
Interactions
Alcohol, CNS depressants, anticoagulants, other NSAIDs, oral hypoglycaemics, antihypertensives, digoxin, cyclosporin, quinolones, diuretics, methotrexate, mifepristone, lithium, corticosteroids.
Advice to Patient
Take with or immediately after meals. Do not break or crush tablets, swallow whole. Contact prescriber if there is difficulty in breathing, dark stools, swelling on face/lips/tongue, blood in vomit, severe abdominal pain, itchy, skin rash. Avoid rich and spicy meals. Keep regular appointments with prescriber.
Pharmacokinetics
Absorption: Well absorbed after oral doses. Rapidly absorbed after IM inj. Metabolism: Hepatic. Bioavailability: Absolute: 100%. Half-life elimination: 42-81 hrs. Time to peak, plasma: Fasting: 2 hrs. With meals: 6 hrs. Excretion: Urine (mainly). Faeces (to a lesser extent).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.