Sulphasalazine

Other Alimentary Tract Preps · Salicylate-sulphonamide

Indications

Ulcerative colitis. Crohn's disease. Rheumatoid arthritis not responding to NSAIDs.

Dosage

Ulcerative colitis, crohn's disease: Adults: 2-4 tab for 2-3 wk; maintenance, 4 tab daily in divided doses. Children: Under 2 yr, not recommended; others, 40-60 mg/kg body-wt. daily; maintenance, 20-30 mg/kg body-wt. daily. Rheumatoid arthritis: Adults: Initially 1 daily for 1 wk, increasing by 1 each wk to max 6 daily in divided doses. Children: Under 2 yr, not recommended. Treatment of acute attack of mild to moderate and severe ulcerative colitis, active Crohn’s disease: 2-12 yr, 10-15 mg/kg (max 1 gm) 4-6 times daily until remission occurs; increased to max 60 mg/kg daily in divided doses, if necessary; 12-18 yr, 1-2 gm 4 times daily until remission occurs. Maintenance of remission of mild to moderate and severe ulcerative colitis: 2-12 yr, 5-7.5 mg/kg (max 500 mg) 4 times daily; 12-18 yr, 500mg 4 times daily.

Adverse Effects

Nausea, headache, rash, fever, loss of appetite.

Risk Factor (Pregnancy/Lactation)

Precautions: Reduce concurrent analgesics only after clinical response is seen. Perform regular blood checks. Impaired renal or hepatic function.

Interactions

Digoxin.

Unlicensed Use

Children: Juvenile idiopathic arthritis: 2-18 yr, Initially 5 mg/kg twice daily for 1 wk, then 10 mg/kg twice daily for 1 wk, then 20 mg/kg twice daily for 1 wk, maintenance dose 20-25 mg/kg twice daily. Max daily 2 gm for 2-12 yr and 3 gm for 12-18 yr.

Brands with this active ingredient

• Salazine
• Salazodine

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.