Streptomycin
Antituberculosis Preps · Aminoglycoside
Indications
Treatment of tuberculosis only in conjunction with other anti-tuberculous drugs.
Dosage
Adults: IM: 15-30 mg/kg/day when used as a daily therapy. Max 1 gm. Children: IM: 20-40 mg/kg/day when used as a daily therapy. Max 1 gm/day.
Administration
Reconstitute with 4.2, 3.2, or 1.8 mL of SWFI to yield solutions containing 200, 250, or 400 mg/mL, respectively. Administered by deep IM injection well within the body of a relatively large muscle. IV route is not recommended. Stability: Reconstituted solutions are stable for 1 week at room temperature and protect from light.
Adverse Effects
Nephrotoxicity and ototoxicity.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Caution advised or effect undetermined. Contraindications: Hypersensitivity. Precautions: Use with caution in patients with pre-existing vertigo, tinnitus, hearing impairment.
Interactions
Depolarizing and non-depolarizing neuromuscular blocking agents, amphotericin, loop diuretics.
Advice to Patient
Therapy may last several months. Contact prescriber if there is vertigo, change in hearing, feeling of fullness in ears, loss of hearing, numbness, pain, tremors, weakness in muscles, change in gait, back pain, change in urinary pattern, chest pain, difficulty in breathing. Complete full course of therapy even if you feel better. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber.
Pharmacokinetics
Absorption: Oral: Poorly absorbed. IM: Well absorbed. Half-life elimination: Newborns: 4-10 hrs. Adults: Approx. 2-4.7 hrs; prolonged with renal impairment. Time to peak: IM: Within 1-2 hrs. Excretion: Urine (29%-89%). Small amount (1%) excreted in bile, saliva, sweat and tears.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.