Sodium Clodronate
Drugs affecting Bone Metabolism · Bisphosphonate
Indications
Osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastasis in breast cancer or multiple myeloma.
Dosage
ORAL: Adults: 1.6 gm once daily in the morning; max 3.2 gm daily in two divided doses. Doses should be taken =2 hr after and =1 hr before food. Children: Not recommended. INJECTION: Adults: Initially 300 mg daily by slow IV infusion for up to 7 days. Maintenance use capsules. Children: Not recommended.
Administration
Continuous in Glucose 5% or NaCl 0.9%. Dilute 300 mg in 500 mL & give over at least 2 hours or 1.5 gm in 500 mL & give over at least 4 hours.
Adverse Effects
GI upset, renal dysfunction, asymptomatic hypocalcaemia. Transient proteinuria. Reversible elevations of parathyroid hormone, creatinine, lactate dehydrogenase, transaminase, alkaline phosphatase. Rarely: Skin reactions.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe renal impairment (CrCl <10 mL/min). Precautions: Moderate renal impairment (CrCl 10-49 mL/min). Monitor renal and hepatic function and white cell counts. Monitor serum calcium and phosphate periodically. Risk of rare osteonecrosis of the jaw usually associated with dental procedures or with concomitant risk factors such as cancer, chemotherapy, radiotherapy or corticosteroid treatment, smoking, history of dental disease and poor oral hygiene.
Interactions
Other biphosphonates, antacids, mineral supplements, NSAIDs, aminoglycosides, estramustine.
Advice to Patient
Maintain adequate fluid intake. Avoid invasive dental procedures and advise reporting of any oral symptoms while on treatment, consider dental examination prior to treatment.
Pharmacokinetics
Absorption: Oral: Poorly absorbed. Metabolism: Not metabolized. Bioavailability: Oral: 1-4%. Half-life elimination: Terminal: 13 hrs. Time to peak, plasma: 0.5-1 hr. Excretion: Urine (mainly). Faeces (5% of IV dose; 50% of oral dose).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.