Rabeprazole
Antipeptic Ulcerant · Proton pump inhibitor
Indications
Active duodenal or active benign gastric ulcer, erosive or ulcerative GERD. Long term maintenance in GERD. Symptomatic non-erosive GERD. Zollinger-Ellison syndrome. Severe oesophagitis. With antibiotics for eradication of H. pylori in peptic ulcer disease.
Dosage
The dosage should be swallowed before food. Adults: Duodenal ulcer: 20 mg once daily in the morning for 4-8 wk. Gastric Ulcer: 20 mg once daily in the morning for 6-12 wk. GERD: 20 mg once daily in the morning for 4-8 wk. GERD maintenance: 20 mg or 10 mg once daily. Symptomatic GERD: 10 mg once daily for up to 4 wk. Then 10 mg once daily as required. Zollinger-Ellison syndrome: Initially 60 mg once daily increasing if necessary to 120 mg daily (doses greater than 100 mg may require to be divided into a twice daily regimen). Continue treatment as long as required. Severe oesophagitis: 20 mg once daily for 8 wk, if necessary continue as maintenance treatment. Triple therapy vs H. pylori: Rabeprazole sodium 20 mg with clarithromycin 500 mg and amoxicillin 1 gm all twice daily for 7 days. Children: Not recommended.
Adverse Effects
Headache, GI upset, rash, asthaenia, dry mouth.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Precautions: Exclude gastric or oesophageal malignancy before treatment. Severe hepatic impairment. Monitor patients on long term therapy.
Interactions
Ketoconazole, itraconazole.
Advice to Patient
Tab: Take with or without meals. Do not chew or crush tablet. Swallow whole with full glass of water. When used for the treatment of duodenal ulcers, take after a meal. When used for the eradication of H. pylori, take with the morning and evening meals. Cap: Take 30 min before meals. If there is difficulty in swallowing tablets , open the capsule and mix capsule contents with small amount of applesauce, fruit or vegetable based baby food or yoghurt. Swallow whole mixture. Complete the dose within 15 minutes.
Pharmacokinetics
Onset of action: Within 1 hr. Duration: 24 hrs. Absorption: Oral: Well absorbed within 1 hr, food delayed absorption up to 4 hrs or longer. Metabolism: Hepatic. Bioavailability: Tab: Approx. 52%. Half-life elimination (dose dependant): Adolescents: Approx. 0.55-1 hr. Adults: 1-2 hrs. Mild to moderate hepatic impairment: Two-to threefold higher comparatively to adults. Time to peak, plasma: Adolescents: Tab: 3.3-4.1 hrs. Adults: Tab: 2-5 hrs. Cap: 1-6.5 hrs. Excretion: Urine (90%), faeces.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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