Pyrazinamide
Antituberculosis Preps · Antibacterial
Indications
Treatment of tuberculosis only in conjunction with other anti-tuberculous drugs.
Dosage
Adults & Children: 15-30 mg/kg daily in divided doses; max 2 gm daily.
Adverse Effects
Hepatitis which can be minimized by dosage adjustment. Hepatic reactions, active gout, sideroblastic anaemia, arthralgia, hyperuricaemia, anorexia, GI upset, flushing, dysuria, malaise, fever, rash, aggravation of peptic ulcer, wt loss, photosensitivity.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Liver disease, hyperuricaemia or gouty arthritis, acute porphyria. Precautions: Perform frequently liver function tests and blood uric acid determinations. History of gout or diabetes. Withdraw treatment if liver damage or hyperuricaemia accompanied by acute gouty arthritis occurs. Renal impairment.
Interactions
Probenecid, sulfinpyrazone, oral typhoid vaccine, combined hormonal contraceptives, alcohol, aspirin, ascorbic acid, hypoglycaemics, rifampicin, iodinated contrast agents.
Advice to Patient
Take with meals. Contact prescriber if you experience colour change in urine, pale stools, difficulty in urination, blood in urine, easy bleeding or bruising, yellowing of skin or eyes, extreme joint pain, severe pain in feet or toes, unrelieved nausea or vomiting, unusual fever. Regularly follow-up medical and laboratory tests as advised by prescriber. Avoid direct sunlight, wear sunscreen, proper eyewear and protective clothing to prevent photosensitivity.
Pharmacokinetics
Absorption: Well absorbed. Metabolism: Hepatic. Half-life elimination: 9-10 hrs, prolonged with reduced renal or hepatic function. Time to peak, serum: Within 2 hrs. Excretion: Urine (4%).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.