Propofol

Anaesthetic · General anaesthetic

Indications

Short-acting IV anaesthetic for induction and maintenance of general anaesthesia. For sedation of ventilated patients receiving intensive care.

Dosage

See literature.

Administration

Before use, propofol should be shaken well. It may be administered undiluted by IV injection or infusion or diluted with dextrose 5% to not less than 2 mg/mL. Compatibility: Stable in D5LR, D5 1/4NS, D5 1/2NS, D5W, LR. Y-site administration: Drug to Drug IV Compatibility: Acyclovir, aztreonam, bumetanide, calcium gluconate, cephazolin, ceftriaxone, cimetidine, dexamethasone, diphenhydramine, dobutamine, dopamine, enalapril, epinephrine, esmolol, famotidine, fentanyl, fluconazole, furosemide, heparin, hydrocortisone, hydromorphone, imipenem, insulin regular, labetalol, lorazepam, magnesium sulphate, milrinone, nitroglycerin, nitroprusside, norepinephrine, ondansetron, ranitidine, vecuronium. Drug to Drug IV Incompatibility: Amikacin, amphotericin B, atracurium, bretylium, ciprofloxacin, cisatracurium, diazepam, digoxin, doxorubicin, gentamicin, levofloxacin, methotrexate,…

Adverse Effects

Hypotension, inj site burning, pain, apnoea, pruritus, rash, hyperlipidaemia, respiratory acidosis during weaning.

Risk Factor (Pregnancy/Lactation)

Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Contraindications: Children, severe cardiovascular and respiratory disease, epilepsy or seizures, hyperlipidaemia, hypotension, cesarean section deliveries. Precautions: Elderly, avoid abrupt discontinuation, avoid using with blood or blood products through the same IV catheter.

Interactions

Neuromuscular blockers, benzodiazepines, opiates, ethanol, narcotics, phenothiazines.

Pharmacokinetics

Onset of action: Anaesthetic: Bolus infusion (dose dependent): 9-51 seconds (average 30 seconds). Duration: 3-10 mins depending on the dose, rate and duration of administration. Metabolism: Hepatic. Half-life elimination: Biphasic: Initial: 40 mins. Terminal: 4-7 hrs (after 10-day infusion, may be up to 1-3 days). Excretion: Urine (approx. 88% as metabolites, 40% as glucuronide metabolite). Faeces (<2%).

Brands with this active ingredient

• Diprivan
• Dipropofol
• Fresofol
• Phebol
• Pofol
• Proanes
• Propofol
• Propofol Lipuro
• Recofol

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.