Pancuronium Bromide
Muscle Relaxant · Non-depolarising muscle relaxant
Indications
As an adjuvant in adult/child surgical anaesthesia to obtain relaxation so that operative manipulations are facilitated.
Dosage
Adults: Surgery: Initial dose 0.02-0.06 mg/kg, incremental dose 0.01-002 mg/kg. If the recommended doses of pancuronium are exceeded, this will increase the risk of prolonged neuromuscular block, difficulties with the reversal and marked side-effects. In heavy or obese patients calculation of the dosage of pancuronium on the basis of mg/kg leads to over dosing. Children: IV injection: Neonate, initially 100 mcg/kg, then 50 mcg/kg repeated as necessary, 1 mth-18 yr, initially 100 mcg/kg, then 20 mcg/kg repeated as necessary.
Administration
IV: May be administered undiluted by rapid IV injection. Compatibility: Stable in D5NS, D5W, LR, NS. Stability: Refrigerate, however is stable for up to 6 months at room temperature.
Adverse Effects
Moderate rise of mean arterial pressure may occur. Decreases intraocular pressure and induces miosis.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Precautions: Only be used in hospitals which possess suitable equipment and it should be administered by a fully qualified anaesthetist. Administration of depolarizing drugs following a non-depolarizing drug is not advisable. Do not mix with other solutions.
Advice to Patient
Before administration, patient is usually unconscious. Continuous monitoring is required during and after administration. After muscle tone becomes normal, do not change position and rise up without help. Contact prescriber if difficulty in breathing, muscle tremors, fast heartbeat, skin rash, hives occur.
Pharmacokinetics
Onset of action: Infants: 2 to 5 minutes. Children: 2 to 4 minutes. Adults: 3 to 5 minutes. Duration (dose dependent): Children: 24 minutes. Adults: 22 minutes. Metabolism: Hepatic (30% to 45%). Half-life elimination: 89 to 161 minutes. Excretion: Urine (40%); bile (11%).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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