Oxaprozin
Anti-rheumatic, Systemic · Propionic acid
Indications
Inflammatory and painful conditions of rheumatoid arthritis, osteoarthritis, gouty arthritis, ankylosing spondylitis, bursitis, tendinitis, sciatica. Dental pain and inflammation, dysmenorrhoea, post-operative and post-traumatic pain.
Dosage
Adults: 600 mg once a day. In acute Painful condition, initially 1200 mg daily. Max dose 26 mg/kg/day. Children: Not recommended.
Adverse Effects
Nausea, diarrhoea, constipation, gastralgia, vomiting, headache, skin rash, pruritus.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Active peptic ulceration, hypersensitivity to oxaprozin, individuals with complete or partial syndrome of nasal polyps. Precautions: Impaired hepatic or renal impairment, upper gastro-intestinal disease.
Interactions
Aspirin, warfarin or any drug that affect platelet function.
Advice to Patient
Take with meals. Do not chew, crush or break tablets, swallow whole with a glass of water. Do not lie down for 15-30 minutes after taking medication. Discontinue medication and inform prescriber immediately if there is constant stomach pain/cramps, indigestion or blood in stool. Contact prescriber if there is unusual cough, difficulty in breathing, chest pain, palpitations, fast heartbeat, vaginal bleeding, unusual bruising or bleeding, blood in urine, mouth or vomitus, swelling in extremities, acute fatigue, skin rash, itching, blisters, fever, swelling of face/lips/tongue/throat, difficulty in speaking. Avoid alcohol during therapy. Take sufficient amount of fluids (2-3 litres per day) to maintain hydration, unless restricted by the prescriber. Do not take aspirin, aspirin containing medications, anti-inflammatory medications without consulting prescriber. Check your weight every week…
Pharmacokinetics
Absorption: Slowly but extensively absorbed from the GI tract. Metabolism: Hepatic. Bioavailability: 95%. Half-life elimination: 44 hrs. Time to peak, plasma: 2-3 hrs. Excretion: Urine (65%). Faeces (35%).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.