Glipizide

Hypoglycaemic excluding Insulin · Sulphonylurea

Indications

Type II diabetes.

Dosage

Adults: Initially 2.5 mg or 5 mg daily up to 30 min before breakfast or midday meal. Titrate by 2.5-5 mg at weekly intervals; max 20 mg daily. Doses above 15 mg daily should usually be divided. Children: Not recommended.

Adverse Effects

Hypoglycaemia, GI upset, skin reactions. Rarely, hepatic function abnormalities, hepatic failure, hepatitis, jaundice, blood dyscrasias, transient visual disturbances.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Ketoacidosis, diabetic pre-coma and coma, severe renal or hepatic impairment. Porphyria. Concomitant miconazole treatment. Precautions: Mild to moderate renal or hepatic impairment, obesity. Adrenal or pituitary insufficiency. Surgery, severe trauma, infections, G6PD deficiency. Elderly.

Interactions

NSAIDs, salicylates, phenylbutazone, oral anticoagulants, MAOIs, ACE inhibitors, beta-blockers, chloramphenicol, azole antifungals, cimetidine, corticosteroids, diuretics, phenothiazines, quinolones, alcohol.

Advice to Patient

Take 30 minutes before the first meal of the day. Take extended release tablet with breakfast. Do not chew or crush extended release tablets. Do not skip the meal after taking medication. Contact prescriber if there is severe or persistent hypoglycaemia, palpitations, sweaty palms, lightheadedness, extended vomiting or flu-like symptoms, skin rash, sore throat, easy bruising or bleeding or change in color of urine or stool. Carry candy or other simple sugars to treat mild hypoglycaemia. Carry identification card indicating diabetes. Avoid direct sunlight, use protective clothing, wear sunscreen and eyewear to prevent photosensitivity. Avoid alcohol. Do not take any other medication within 2 hours of taking glipizide. Monitor glucose level as advised by the prescriber. If glipizide is used during pregnancy, discontinue and change to Insulin at least 1 month prior to delivery to reduce…

Pharmacokinetics

Duration: 12-24 hrs. Absorption: Immediate release: Rapid and complete, delayed with food. Bioavailability: 90%-100%. Metabolism: Hepatic. Half-life elimination: 2-5 hrs. Time to peak: 1-3 hrs. Extended release tab: 6-12 hrs. Excretion: Urine (90%). Faeces (10%).

Brands with this active ingredient

• Gleezid
• Glipase
• Minidiab
• Minidiab AF

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.