Eprosartan

Angiotensin-II Antagonist · Angiotensin II antagonist

Indications

Hypertension.

Dosage

Adults: Initially 600 mg once daily with food; max 800 mg once daily. Elderly: Over 75 yr, initially 300 mg once daily with food. Children: Not recommended.

Adverse Effects

Dizziness, arthralgia, rhinitis, flatulence, hypertriglyceridaemia.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe hepatic impairment. Precautions: Renal impairment, mild to moderate hepatic impairment, sodium or volume depletion, hyperkalaemia. Monitor serum electrolytes.

Interactions

K+ sparing diuretics, K+ supplements, other antihypertensives, lithium, NSAIDs.

Advice to Patient

Take as directed by prescriber. Change position slowly when climbing stairs and from lying or sitting to standing position. Maximum blood pressure response may not occur for 3 to 4 weeks. Contact prescriber if there is chest pain; palpitations; respiratory infection; cold symptoms; unusual cough; swelling of face, tongue, lips, hands, feet; changes in urinary pattern or extreme fatigue.

Pharmacokinetics

Metabolism: Minimally hepatic. Bioavailability: 300 mg dose: 13%. Half-life elimination: Terminal: 5-9 hrs. Time to peak, serum: Fasting: 1-2 hrs. Excretion: Faeces (90%). Urine (7%).

Brands with this active ingredient

• Teveten

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.