Doxylamine and Vitamin B6

Antiemetic & Gastroprokinetic · Antihistamine/Vitamin

Indications

Symptoms of nausea and vomiting in pregnant women.

Dosage

Adults: For mild symptoms, 2 tab at bedtime. If needed 1 tab in morning, 1 tab in afternoon and 2 tab at bedtime. Children: Not recommended.

Adverse Effects

Somnolence, dyspnoea, palpitation, tachycardia, vertigo, blurred vision, visual disturbances, abdominal distension, abdominal pain, constipation, diarrhoea, chest discomfort, fatigue, irritability, malaise, hypersensitivity, dizziness, headache, migraine, paresthesia, psychomotor hyperactivity, dis-orientation, insomnia, night-mares, dysuria, urinary retention, hyperhidrosis, pruritus, rash, rash maculopapular.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Controlled studies shown no risk. Lactation: Contraindicated or not recommended. Precautions: Asthma, increased intraocular pressure, narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction and urinary bladder-neck obstruction.

Interactions

MAOIs, CNS depressants such as hypnotics, sedatives, tranquillisers.

Pharmacokinetics

DOXYLAMINE: Onset: Oral: 30 mins. Absorption: Readily absorbed via GI tract. Metabolism: Hepatic. Bioavailability: Oral: 24.7%. Intranasal: 70.8%. Half-life elimination: 10 hrs. Time to peak, plasma: Oral: 2-3 hrs. Excretion: Urine (60%). Faeces (40%). VITAMIN B6: Absorption: Readily absorbed from the GI tract. Metabolism: Hepatic. Half-life elimination: 15-20 days. Time to peak: 5.5 hrs. Excretion: Urine.

Brands with this active ingredient

• Doxyfaas
• Doxypride
• Envepe
• Femiroz
• Morease
• Morniglo DR
• Natalia
• Nausidox
• Nomo-D
• Omit
• Ubelkeit
• Vepev
• Vomipreg
• Xyquil

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.