Diclofenac Sodium and Omeprazole

Anti-rheumatic, Systemic · Phenylacetic acid/Proton pump inhibitor

Indications

Symptomatic treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis in patients at risk of developing NSAID associated gastric and/or duodenal ulcers.

Dosage

Adults: 1 cap once daily. Children: Not recommended.

Adverse Effects

Headache, dizziness, giddiness, feeling sick, flatulence, diarrhoea, loss of appetite, stomach pain, other abnormal symptoms, indigestion, heartburn, changes in blood test, rash.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Caution advised or effect undetermined. Precautions: Elderly. SLE. Crohn’ disease or ulcerative colitis. Asthma, hayfever, nose polyps, COPD. Hypertension. Hepatic or renal impairment. Difficulty swallowing. Increased weight. Cardiac problem. History of stroke.

Interactions

Nelfinavir, saquinavir, lithium, NSAIDs, anti-hypertensives, anti-diabetics, ciprofloxacin, ciclosporin, tacrolimus, corticosteroids, digoxin, SSRIs, methotrexate, zidovudine, colestipol, cholestyramine, sulfinpyrazone, diazepam, phenytoin, rifampicin, atazanavir, St. John’s wort, cilostazol, clopidogrel, erlotinib, clarithromycin, anti-fungals.

Advice to Patient

Swallow whole with a glass of water. Do not chew, break or open the capsules. Take with or after meals. Take at the same time everyday. Do not drive or operate machinery if you feel dizziness after taking medication.

Pharmacokinetics

DICLOFENAC SODIUM: Absorption: Oral: Approx. 50% (systemically available). Metabolism: Hepatic; undergoes first-pass metabolism; forms several metabolites (1 with weak activity). Bioavailability: 55%. Half-life elimination: Oral: Approx. 2 hours; approx. 1 hour (liquid filled capsule); inj : Approx. 1.4 hours. Time to peak, serum: Note: Fasted values reported for oral products; may be delayed with food. Injection: Approx. 5 minutes. Tablet, delayed release (diclofenac sodium): 2.3 hours. Tablet, extended release (diclofenac sodium): 5.3 hours. Excretion: Urine (approx. 65%); bile (approx. 35%). OMEPRAZOLE: Onset of action: Approx. 1 hr. Peak effect: Within 2 hrs. Duration: Up to 72 hrs. Maximum secretory inhibition: 4 days. Absorption: Rapid. Metabolism: Hepatic. Bioavailability: Oral: Approx. 30%-40%. Hepatic dysfunction: Approx. 100%. Half-life elimination: 0.5-1 hr. Hepatic…

Brands with this active ingredient

• Lovanzo-D
• Omega-D

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.