Dexketoprofen And Tramadol

Narcotic Analgesic · Opiate analogue/Propionic acid

Indications

Symptomatic short treatment of moderate to severe acute pain.

Dosage

Adults: 1 tab daily. Dose can be increased, as required with a min dosing interval of 8 hrs. Max: 3 tabs daily. Do not take for more than 5 days. Elderly: Initial: 1 tab daily. Max: 2 tab daily. Children: Not recommended.

Adverse Effects

Somnolence, abdominal pain, constipation, dry mouth, dyspepsia, nausea, vomiting, hyperhidrosis, fatigue.

Risk Factor (Pregnancy/Lactation)

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Severe hepatic impairment. Moderate to severe renal impairment. Active peptic ulcer/GI hemorrhage, history of GI bleeding ulceration or perforation related to previous NSAIDs therapy. Chronic dyspepsia. Other active bleedings or bleeding disorders. Crohn’s disease or ulcerative colitis. Severe heart failure. Haemorrhagic diathesis and other coagulation disorders. Severe dehydration. Epilepsy not adequately controlled by treatment. Severe respiratory depression. Precautions: Mild to moderate hepatic impairment. Mild renal impairment. Uncontrolled hypertension. Mild to moderate CHF. Established ischaemic heart disease. Peripheral arterial disease. Cerebrovascular disease. Diabetes mellitus. Smoking. Elderly. Congenital disorder of porphyrin metabolism (e.g. acute intermittent…

Interactions

Warfarin, other coumarins, heparins. Other NSAIDs, corticosteroids, lithium, methotrexate, hydantoines (including phenytoin and sulphonamides. Diuretics, ACE inhibitors, antibacterial aminoglycosides, angiotensin II receptor antagonists. Pentoxyfilline. Zidovudine. Sulfonylureas. Beta-blockers. Cyclosporin and tacrolimus. SSRIs. Probenecid. Cardiac glycosides. Thrombolytics, anti-platelet agents. Mifepristone. Quinolone antibiotics. Tenofovir. Deferasirox. Pemetrexed. MAOIs. Mixed agonist/antagonist opioid receptors (e.g. buprenorphine, nalbuphine, pentazocine). TCAs. SSRIs. SNRIs. Antipsychotics. Mirtazapine. Sedatives. Ketoconazole. Erythromycin.

Advice to Patient

Take with a sufficient amount of fluid (e.g. 1 glass of water). Swallow whole tab. Do not crush or chew. Tab may be taken at least 30 mins before meals. Do not drive, operate machinery or perform tasks that require mental alertness due to risk of dizziness and drowsiness during treatment. Avoid alcohol during treatment.

Pharmacokinetics

DEXKETOPRFEN: Absorption: Rapidly absorbed from the GI tract. Delayed absorption with food. Metabolism: Hepatic. Half-life elimination: 1-2.7 hrs. Time to peak, plasma: Tab: 15-60 mins. Granules for oral soln: 15-20 mins. IM: 10-45 mins. Excretion: Urine (primarily as metabolites). TRAMADOL: Onset of action: Immediate release: Within 1 hr; Peak effect: 2-3 hrs. Metabolism: Extensively hepatic. Bioavailability: Immediate release: Approx. 75%. Extended release: Approx. 85%-95% (as compared to immediate release). Half-life elimination: Immediate release: 6.3 ± 1.4 hrs; active metabolite (M1): 7.4 ± 1.4 hrs; prolonged in elderly. Extended-release: Cap: Approx. 10 hrs; active metabolite (M1): Approx. 11 hrs. Tab: Approx. 7.9 hrs; active metabolite (M1): 8.8 hrs. Time to peak, plasma: Immediate release: Approx. 2 hrs; active metabolite (M1): 3 hrs. Extended release: Approx. 4-12 hrs; active…

Brands with this active ingredient

• Dexket-T
• Dolketo-T
• Tramal-D

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.