Dexibuprofen
Anti-rheumatic, Systemic · Propionic acid
Indications
Osteoarthritis, dysmenorrhoea, mild to moderate pain, dental pain.
Dosage
Adults: 600-900 mg daily in up to three divided doses; increased if necessary to max 1200 mg daily in three divided doses, max single dose 400 mg. Dysmenorrhoea: 900 mg daily, single dose of 300 mg. Children: Not recommended.
Adverse Effects
GI upset, abdominal pain, rash (discontinue immediately), fatigue, drowsiness, headache, dizziness, vertigo.
Risk Factor (Pregnancy/Lactation)
Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Active peptic ulcer or GI bleeding, aspirin/anti-inflammatory allergy, severe hepatic impairment, severe renal impairment, inflammatory bowel disease, severe congestive heart failure, coagulation disorders, Crohn's disease or ulcerative colitis, cerebrovascular bleeding, varicella. Precautions: Mild to moderate hepatic or renal impairment, history of GI ulceration or bleeding, alcoholism, ulcerative colitis, SLE, history of asthma, hypertension, CHF, ischaemic heart, peripheral arterial or cerebrovascular disease. Cardiovascular risk factors. Use lowest effective dose for shortest duration. Monitor patients on long term therapy. Elderly.
Interactions
Anticoagulants, diuretics, quinolones, antihypertensives, ACE inhibitors, cardiac glycosides, lithium, methotrexate, cyclosporin, tacrolimus, mifepristone, other NSAIDs, corticosteroids, phenytoin, sulfonylureas, probenecid, sulfinpyrazone, ticlopidine, zidovudine, antiplatelets, SSRIs, digoxin, sirolimus, aminoglycosides, phenobarbital, rifampicin, pemetrexed, sulfonylureas, trimethoprim, zidovudine.
Pharmacokinetics
Absorption: Rapid. Time to peak, plasma: 2-5 hrs. Excretion: Urine (mainly).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.