Dexamethasone, Chloramphenicol and Tetrahydrozoline, Eye
Corticosteroid Combinations, Eye · Chloramphenicol/Corticosteroid/Sympathomimetic
Indications
Conjunctivitis and keratitis of allergic and infectious origin, marked by severe swelling and multiple vascular congestion. Inflammation of anterior uvea, scleritis, episcleritis, myositis and sympathetic ophthalmia. Post-operative treatment after eye surgery.
Dosage
Adults: 1 drop 1-4 times daily, in acute cases the drop may be used after every one hr.
Adverse Effects
Aplastic anaemia, reversible rise in intraocular pressure after prolonged application.
Risk Factor (Pregnancy/Lactation)
Contraindications: Injuries and ulcerative conditions of the cornea, herpes simplex, vaccinia, TB infections, mycosis, glaucoma. Precautions: Chronic use, posterior subcapsular cataract, thinning of cornea, secondary infection, overgrowth of non-susceptible organisms, children.
Advice to Patient
Wash hands properly before use. To instill medication into eyes, tilt head back, look upward, instill drops or apply thin layer of ointment inside lower eyelid. Close eye and roll eyeball in all directions. Do not blink for 30 seconds. Apply gentle pressure to inner corner of eye for 30 seconds. Contact prescriber if there is eye pain, changes in vision, no improvement or worsening of condition. Avoid touching tip of applicator with eye. Avoid prolonged use. Do not use any other eye preparation for atleast 10 minutes. Do not share medication with anyone else. Wear sunglasses when in sunlight to prevent photosensitivity.
Pharmacokinetics
DEXAMETHASONE: Absorption: Well-absorbed. CHLORAMPHENICOL: Absorption: Well absorbed. Metabolism: Hepatic. Half-life elimination: Adults (normal hepatic and renal function): 1.5-3.5 hrs. Impaired renal function: 3-4 hrs. Severely impaired hepatic function: 4.6-11.6 hrs. Children (1 mth-16 yrs): 3-6.5 hrs. Infants 1-2 days old: 24 hrs or longer and is highly variable, esp in low birth-wt infants. TETRAHYDROZOLINE: Onset: Few mins. Duration: 1-4 hrs. Absorption: Well-absorbed.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
Always consult a pharmacist or doctor.