Cyclobenzaprine
Muscle Relaxant · Skeletal muscle relaxant
Indications
Treatment of muscle spasm associated with acute painful musculoskeletal conditions.
Dosage
Do not use longer than 2-3 wk. Adults: Initial: 5 mg 3 times/day; may increase to 10 mg 3 times/day if needed. Elderly: 5 mg 3 times/day. Children: Not recommended.
Adverse Effects
Drowsiness, dizziness, xerostomia.
Risk Factor (Pregnancy/Lactation)
Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Contraindications: Do not use concomitantly or within 14 days of MAO inhibitors; hyperthyroidism; congestive heart failure; arrhythmias; acute recovery phase of MI. Precautions: Cyclobenzaprine shares the toxic potentials of the tricyclic antidepressants and the usual precautions of tricyclic antidepressant therapy should be observed; use with caution in patients with urinary hesitancy, angle-closure glaucoma, hepatic impairment, or in the elderly.
Interactions
CYP1A2 inhibitors. TCAD, anticholinergics. CNS depressants, MAO inhibitors, tramadol.
Advice to Patient
Take as directed by prescriber. Contact prescriber if there is mental agitation, increased drowsiness, skin rash, chest pain, swelling of mouth or face, difficulty in speaking, blurred vision, ringing in ears. Avoid alcohol during therapy. Do not take OTC medications especially antidepressants, sedatives, pain medications without consulting prescriber. Urinate before taking medication.
Pharmacokinetics
Onset of action: Immediate release tablet: Within 1 hour. Duration of action: Immediate release tablet: 12 to 24 hours. Metabolism: Hepatic. Bioavailability: 33% to 55%. Half-life elimination: Normal hepatic function: Range: 8 to 37 hours. Immediate release tablet: 18 hours. Extended release capsule: 32 hours. Impaired hepatic function: 46.2 hours (range: 22.4 to 188 hours) Time to peak, serum: Immediate release tablet: Approx. 4 hours. Extended release tablet: 7 to 8 hours. Excretion: Urine, feces.
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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