Clindamycin, Inj/Oral
Macrolide & similar types · Lincosamide
Indications
Serious clindamycin sensitive infections.
Dosage
ORAL: Adults: 150-450 mg six hourly. Children: Under 1 yr, 2.5-5 mL; 4-7 yr, 5-7.5 mL; 8-12 yr, 7.5-10 mL. All six hourly. Lower Respiratory Infection: Adults: 150-450 mg every 6 hr. Children: 8-20 mg/kg/day given in 3-4 doses. Bone Infection: Adults: 150-450 mg every 6 hr. Children: 8-20 mg/kg/day given in 3-4 doses. Skin Infection: Adults: 150-450 mg every 6 hr. Children: 8-20 mg/kg/day given in 3-4 doses. Bacterial Vaginosis: Pregnant/Non-Pregnant: 300 mg every 12 hr for 7 days. INJECTION: Adults: 600 mg-2.7 gm by IM, inj or IV infusion daily in divided doses. Children: Over 1 mth, 15-40 mg/kg daily in divided doses. Lower Respiratory Infection: IM/IV: Adults: 600-2700 mg/day in 2-4 doses. Max: 600 mg IM single dose. Children: 1 mth-16 yr: 20-40 mg/kg/day in 3-4 doses. < 1 mth: 15-20 mg/kg/day Bone Infection: IM/IV: Adults: 600-2700 mg/day in 2-4 doses. Max: 600 mg IM single dose.…
Administration
IM: Deep IM, rotate sites. Do not exceed 600 mg in a single injection. IV: Never give as bolus. Administer by IV intermittent infusion over at least 10-60 min, at a rate not to exceed 30 mg/min; final concentration for administration should not exceed 12 mg/ mL. Reconstitution: Dilute 300 mg in 50 mL of diluent and give over 10 mins. Dilute 600 mg in 100 mL of diluent and give over 20 mins. Dilute 900 mg in 100 mL of diluent and give over 30 mins. Compatibility: Stable in D5LR, D5½NS, D5NS, D5W, D10W, LR, NS. At Y-site administration: Incompatible with allopurinol, filgrastim, fluconazole, idarubicin. In syringe: Incompatible with tobramycin. When admixed: Incompatible with aminophylline, barbiturates, calcium gluconate, ceftriaxone, ciprofloxacin, gentamicin with cephazolin, magnesium sulphate, phenytoin. Stability: IV infusion solution in NS or D5W solution is stable for 16 days at…
Adverse Effects
Gl disturbances including pseudomembranous colitis. Jaundice and blood disorders.
Risk Factor (Pregnancy/Lactation)
Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Contraindications: Lincomycin sensitivity. Precautions: Discontinue use if persistent diarrhoea or colitis appear. Renal or hepatic impairment. Atopic patients.
Interactions
Neuromuscular blocking agents, erythromycin, vit K antagonists, strong CYP3A4 inducers.
Advice to Patient
Take with or without meals. To prevent abdominal discomfort, take with meals. Swallow whole with a glass of water when sitting in an upright position. Contact prescriber if there is dizziness, diarrhoea, abdominal pain, vomiting, inflammation in mouth, skin rash, redness, burning fever, chills, unusual bleeding or bruising, excessive fatigue, yellowing of eyes, yellowing of skin, dark stool, bloody or fatty stool, change in colour of urine, warmth/swelling/pain in ankles/feet/hands, difficulty in breathing or if there is worsening of condition or no improvement. Watery or bloody stools can occur 2 or more months after therapy and can be serious, requiring immediate treatment. Do not take any new medication especially antidiarrhoeal without consulting prescriber. Complete full course of therapy even if you feel better. Avoid refrigerating oral suspension.
Pharmacokinetics
Absorption: Oral, hydrochloride: Rapid (90%); clindamycin palmitate must be hydrolyzed in the GI tract before it is active. Metabolism: Hepatic. Bioavailability: Oral: Approx. 90%. Half-life elimination: Neonates: Premature: 8.7 hrs. Full-term: 3.6 hrs. Infants 1 mth-1 yr: 3 hrs. Children: Approx. 2.5 hrs. Adults: 3 hrs. Elderly (oral): Approx. 4 hrs. Time to peak, serum: Oral: Within 60 mins. IM: 1-3 hrs. Excretion: Urine (approx. 10%). Faeces (3.6%).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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