Clemastine
Antihistamine, Systemic · H1 receptor antagonist
Indications
Oral: Allergic conditions e.g. hay fever and other allergic rhinopathies, urticaria, pruritus, itching dermatoses, as adjuvant in acute and chronic eczema, contact dermatitis, drug eruptions, insect stings and bites. Inj: As adjuvant in anaphylactic or anaphylactoid shock and angioneurotic oedema; prevention & treatment of allergic & pseudo-allergic reactions; diagnostic use of antihistamine.
Dosage
INJECTION: Usually anaphylaxis or histamine reactions: Adults: 1 amp IV. Children: 0.025 mg/kg body-wt IV. ORAL: Allergic rhinitis: Adults: Clemastine fumarate 1.34 mg (1 mg base) twice daily, may be increased as needed. Max, 6 mg/day base. Children: 6->12 yrs: Syp: Clemastine fumarate 0.67 mg (0.5 mg base) twice daily, dosage may be increased as needed. Max, 3 mg/day base. =12 yrs: Syp/tab: Same as adults. Common cold/hay fever/upper respiratory allergies: Adults: Clemastine fumarate 1.34 mg (1 mg base) twice daily. Max, 2 mg/day base. Children: =12 yrs: Same as adults. Urticaria/angioedema: Adults: Clemastine fumarate 2.68 mg (2 mg base) twice daily. Max, 6 mg/day base. Children: 6- >12 yrs: Syp: Clemastine fumarate 1.34 mg (1 mg base) twice daily. Max, 3 mg/day base. =12 yrs: Syp/tab: Same as adults.
Administration
Administered by IV injection slowly over 2-3 min. Compatibility: 0.9% NaCl, glucose 5%.
Adverse Effects
Drowsiness, impaired reactions. Rarely dizziness, dry mouth, palpitations, Gl disturbances.
Risk Factor (Pregnancy/Lactation)
Pregnancy: No evidence of risk in humans. Lactation: Contraindicated or not recommended. Contraindications: Porphyria. Precautions: BPH, urinary retention, bladder neck obstruction, glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction. Risk of excitability in children.
Interactions
Alcohol, CNS depressants, MAOIs, TCADs.
Pharmacokinetics
Onset: 15-60 mins. Duration: 10-12 hrs. Absorption: Rapidly and almost completely absorbed from the GI tract. Metabolism: Hepatic. Bioavailability: Approx. 40%. Half-life elimination: 21 hrs. Time to peak, plasma: Oral: 2-4 hrs. Excretion: Urine (mainly).
Brands with this active ingredient
Compiled by Healify Pharmacy from published drug references. How we compile it →
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