Chloramphenicol, Eye

Anti-infective, Eye · Chloramphenicol

Indications

Bacterial conjunctivitis.

Dosage

Eye Drop: Adults & Children: 1-2 drops 4-6 times for 72 hr. May or more frequently if required. May increase interval after 48 hr. Administration should be continued 48 hr after symptoms have disappeared. Eye Oint: Adults & Children: 1 application of oint three or four hourly for 48 hr or more frequently if required. Administration should be for 7 days and continued 48 hr after symptoms have disappeared. Max 3 wk.

Adverse Effects

Local sensitivity reactions. Aplastic anaemia (rare).

Risk Factor (Pregnancy/Lactation)

Pregnancy: Risk cannot be ruled out. Lactation: Contraindicated or not recommended. Contraindications: Myelosuppression with previous chloramphenicol exposure. Personal or family history of blood dyscrasias. Precautions: Contact lenses.

Interactions

Other myelosuppressive drugs.

Advice to Patient

Avoid prolonged use.

Pharmacokinetics

Absorption: Well absorbed. Metabolism: Hepatic. Half-life elimination: Adults (normal hepatic and renal function): 1.5-3.5 hrs. Impaired renal function: 3-4 hrs. Severely impaired hepatic function: 4.6-11.6 hrs. Children (1 mth-16 yrs): 3-6.5 hrs. Infants 1-2 days old: 24 hrs or longer and is highly variable, esp in low birth-wt infants.

Brands with this active ingredient

• Alklorafen
• Biostat
• Chloramphenicol
• Chloramphenicol
• Chlorax
• Chlorin
• Chlormic
• Chloroptic
• Epophenicol Eye
• Invoclor
• Lexicol
• Manophenicol
• Medichlor Plus
• Monophenicol
• Novophenicol

Compiled by Healify Pharmacy from published drug references. How we compile it →

Always consult a pharmacist or doctor.